Ound healing. Adv Clin Chem 48: 137161. 11. West DC, Shaw DM, Lorenz P, Adzick NS, Longaker MT Fibrotic healing of adult and late gestation fetal wounds correlates with enhanced hyaluronidase activity and removal of hyaluronan. Int J Biochem Cell Biol 29: 201210. 12. Toole BP Hyaluronan: from extracellular glue to pericellular cue. Nat Rev Cancer 4: 528539. 13. Tolg C, Hamilton SR, Nakrieko KA, Kooshesh F, Walton P, et al. Rhamm2/2 fibroblasts are defective in CD44-mediated ERK1,two motogenic signaling, top to defective skin wound repair. J Cell Biol 175: 10171028. 14. Kaya G, Rodriguez I, Jorcano JL, Vassalli P, Stamenkovic I Selective suppression of CD44 in keratinocytes of mice bearing an antisense CD44 transgene driven by a Licochalcone A web tissue-specific promoter disrupts hyaluronate metabolism inside the skin and impairs keratinocyte proliferation. Genes Dev 11: 9961007. 15. Chen L, Guo S, Ranzer MJ, DiPietro LA Toll-like receptor four has an necessary function in early skin wound healing. J Invest Dermatol 133: 258267. 16. Ghazi K, Deng-Pichon U, Warnet JM, Rat P Hyaluronan 86168-78-7 site fragments boost wound healing on in vitro cutaneous model by way of P2X7 purinoreceptor basal activation: part of molecular weight. PLoS 1 7: e48351. 17. Bourguignon LY, Wong G, Xia W, Man MQ, Holleran WM, et al. Selective matrix interaction with CD44 and RhoGTPase signaling promotes keratinocyte functions and overcomes age-related epidermal dysfunction. J Dermatol Sci 72: 3244. 18. Gao F, Liu Y, He Y, Yang C, Wang Y, et al. Hyaluronan oligosaccharides market excisional wound healing through enhanced angiogenesis. Matrix Biol 29: 107116. 19. Gao F, Yang CX, Mo W, Liu YW, He YQ Hyaluronan oligosaccharides are potential stimulators to angiogenesis via RHAMM mediated signal pathway in wound healing. Clin Invest Med 31: E106116. 20. Tolg C, Poon R, Fodde R, Turley EA, Alman BA Genetic deletion of receptor for hyaluronan-mediated motility attenuates the formation of aggressive fibromatosis. Oncogene 22: 68736882. 21. Schmits R, Filmus J, Gerwin N, Senaldi G, Kiefer F, et al. CD44 regulates hematopoietic progenitor distribution, granuloma formation, and tumorigenicity. Blood 90: 22172233. 22. Gong D, Shi W, Yi SJ, Chen H, Groffen J, et al. TGFbeta signaling plays a vital part in advertising alternative macrophage activation. BMC Immunol 13: 31. 23. Penn JW, Grobbelaar AO, Rolfe KJ The role of the TGF-beta family members in wound healing, burns and scarring: a critique. Int J Burns Trauma 2: 1828. 24. Sarrazy V, Billet F, Micallef L, Coulomb B, Desmouliere A Mechanisms of pathological scarring: role of myofibroblasts and present developments. Wound Repair Regen 19 Suppl 1: s1015. 25. Weisser SB, McLarren KW, Kuroda E, Sly LM Generation and characterization of murine alternatively activated macrophages. Solutions Mol Biol 946: 225239. 9 6mer HA Stimulates Wound Repair 26. Ploeger DT, Hosper NA, Schipper M, Koerts JA, de Rond S, et al. Cell plasticity in wound healing: paracrine factors of M1/M2 polarized macrophages influence the phenotypical state of dermal fibroblasts. Cell Commun Signal 11: 29. 27. Webber J, Meran S, Steadman R, Phillips A Hyaluronan orchestrates transforming growth factor-beta1-dependent upkeep of myofibroblast phenotype. J Biol Chem 284: 90839092. 28. Harty M, Neff AW, King MW, Mescher AL Regeneration or scarring: an immunologic viewpoint. Dev Dyn 226: 268279. 29. Cao G, Savani RC, Fehrenbach 1407003 M, Lyons C, Zhang L, et al. Involvement of endothelial CD44 during in vivo angi.Ound healing. Adv Clin Chem 48: 137161. 11. West DC, Shaw DM, Lorenz P, Adzick NS, Longaker MT Fibrotic healing of adult and late gestation fetal wounds correlates with improved hyaluronidase activity and removal of hyaluronan. Int J Biochem Cell Biol 29: 201210. 12. Toole BP Hyaluronan: from extracellular glue to pericellular cue. Nat Rev Cancer 4: 528539. 13. Tolg C, Hamilton SR, Nakrieko KA, Kooshesh F, Walton P, et al. Rhamm2/2 fibroblasts are defective in CD44-mediated ERK1,two motogenic signaling, major to defective skin wound repair. J Cell Biol 175: 10171028. 14. Kaya G, Rodriguez I, Jorcano JL, Vassalli P, Stamenkovic I Selective suppression of CD44 in keratinocytes of mice bearing an antisense CD44 transgene driven by a tissue-specific promoter disrupts hyaluronate metabolism inside the skin and impairs keratinocyte proliferation. Genes Dev 11: 9961007. 15. Chen L, Guo S, Ranzer MJ, DiPietro LA Toll-like receptor 4 has an essential function in early skin wound healing. J Invest Dermatol 133: 258267. 16. Ghazi K, Deng-Pichon U, Warnet JM, Rat P Hyaluronan fragments strengthen wound healing on in vitro cutaneous model via P2X7 purinoreceptor basal activation: function of molecular weight. PLoS 1 7: e48351. 17. Bourguignon LY, Wong G, Xia W, Man MQ, Holleran WM, et al. Selective matrix interaction with CD44 and RhoGTPase signaling promotes keratinocyte functions and overcomes age-related epidermal dysfunction. J Dermatol Sci 72: 3244. 18. Gao F, Liu Y, He Y, Yang C, Wang Y, et al. Hyaluronan oligosaccharides market excisional wound healing by means of enhanced angiogenesis. Matrix Biol 29: 107116. 19. Gao F, Yang CX, Mo W, Liu YW, He YQ Hyaluronan oligosaccharides are potential stimulators to angiogenesis by way of RHAMM mediated signal pathway in wound healing. Clin Invest Med 31: E106116. 20. Tolg C, Poon R, Fodde R, Turley EA, Alman BA Genetic deletion of receptor for hyaluronan-mediated motility attenuates the formation of aggressive fibromatosis. Oncogene 22: 68736882. 21. Schmits R, Filmus J, Gerwin N, Senaldi G, Kiefer F, et al. CD44 regulates hematopoietic progenitor distribution, granuloma formation, and tumorigenicity. Blood 90: 22172233. 22. Gong D, Shi W, Yi SJ, Chen H, Groffen J, et al. TGFbeta signaling plays a vital function in advertising option macrophage activation. BMC Immunol 13: 31. 23. Penn JW, Grobbelaar AO, Rolfe KJ The role of the TGF-beta loved ones in wound healing, burns and scarring: a critique. Int J Burns Trauma 2: 1828. 24. Sarrazy V, Billet F, Micallef L, Coulomb B, Desmouliere A Mechanisms of pathological scarring: part of myofibroblasts and present developments. Wound Repair Regen 19 Suppl 1: s1015. 25. Weisser SB, McLarren KW, Kuroda E, Sly LM Generation and characterization of murine alternatively activated macrophages. Strategies Mol Biol 946: 225239. 9 6mer HA Stimulates Wound Repair 26. Ploeger DT, Hosper NA, Schipper M, Koerts JA, de Rond S, et al. Cell plasticity in wound healing: paracrine things of M1/M2 polarized macrophages influence the phenotypical state of dermal fibroblasts. Cell Commun Signal 11: 29. 27. Webber J, Meran S, Steadman R, Phillips A Hyaluronan orchestrates transforming growth factor-beta1-dependent maintenance of myofibroblast phenotype. J Biol Chem 284: 90839092. 28. Harty M, Neff AW, King MW, Mescher AL Regeneration or scarring: an immunologic perspective. Dev Dyn 226: 268279. 29. Cao G, Savani RC, Fehrenbach 1407003 M, Lyons C, Zhang L, et al. Involvement of endothelial CD44 throughout in vivo angi.
