Product Name :
R-IMPP
Description:
R-IMPP (PF-00932239) is an anti-secretagogue of PCSK9 (IC50=4.8 μM), which targets the 80S ribosome to inhibit PCSK9 protein translation.
CAS:
2133832-83-2
Molecular Weight:
389.49
Formula:
C24H27N3O2
Chemical Name:
N-(isoquinolin-1-yl)-3-(4-methoxyphenyl)-N-[(3R)-piperidin-3-yl]propanamide
Smiles :
COC1=CC=C(CCC(=O)N([C@H]2CNCCC2)C2=NC=CC3C=CC=CC=32)C=C1
InChiKey:
OKTGXQMSOIQCTJ-HXUWFJFHSA-N
InChi :
InChI=1S/C24H27N3O2/c1-29-21-11-8-18(9-12-21)10-13-23(28)27(20-6-4-15-25-17-20)24-22-7-3-2-5-19(22)14-16-26-24/h2-3,5,7-9,11-12,14,16,20,25H,4,6,10,13,15,17H2,1H3/t20-/m1/s1
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Rifapentine} MedChemExpress|{Rifapentine} Bacterial|{Rifapentine} Technical Information|{Rifapentine} In stock|{Rifapentine} custom synthesis|{Rifapentine} Epigenetics}
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
R-IMPP (PF-00932239) is an anti-secretagogue of PCSK9 (IC50=4.8 μM), which targets the 80S ribosome to inhibit PCSK9 protein translation.|Product information|CAS Number: 2133832-83-2|Molecular Weight: 389.49|Formula: C24H27N3O2|Chemical Name: N-(isoquinolin-1-yl)-3-(4-methoxyphenyl)-N-[(3R)-piperidin-3-yl]propanamide|Smiles: COC1=CC=C(CCC(=O)N([C@H]2CNCCC2)C2=NC=CC3C=CC=CC=32)C=C1|InChiKey: OKTGXQMSOIQCTJ-HXUWFJFHSA-N|InChi: InChI=1S/C24H27N3O2/c1-29-21-11-8-18(9-12-21)10-13-23(28)27(20-6-4-15-25-17-20)24-22-7-3-2-5-19(22)14-16-26-24/h2-3,5,7-9,11-12,14,16,20,25H,4,6,10,13,15,17H2,1H3/t20-/m1/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : 100 mg/mL (256.{{Panobinostat} web|{Panobinostat} HIV|{Panobinostat} Biological Activity|{Panobinostat} In stock|{Panobinostat} manufacturer|{Panobinostat} Autophagy} 75 mM; Need ultrasonic).PMID:24103058 |Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|R-IMPP stimulates uptake of LDL-C in hepatoma cells by increasing LDL-R levels, without altering levels of secreted transferrin. R-IMPP does not decrease PCSK9 transcription or increase PCSK9 degradation, but causes transcript-dependent inhibition of PCSK9 translation. R-IMPP is able to selectively bind to human, but not E. coli, ribosomes.|Products are for research use only. Not for human use.|
