Product Name :
VX-222
Description:
VX22, is an nonnucleoside NS5B polymerase inhibitor. VX-222 inhibits the 1b/Con1 HCV subgenomic replicon, with 50% effective concentrations (EC(50)s) 5 nM. VX-222 binds to the HCV polymerase with dissociation constants of 17 nM. In phase 1 and 2 clinical studies, VX-222 demonstrated effective antiviral efficacy, with substantial reductions in plasma HCV RNA in patients chronically infected with genotype 1 HCV.
CAS:
1026785-55-6
Molecular Weight:
445.61
Formula:
C25H35NO4S
Chemical Name:
5-(3, 3-dimethylbut-1-yn-1-yl)-3-((1r, 4R)-N-((1r, 4R)-4-hydroxycyclohexyl)-4-methylcyclohexane-1-carboxamido)thiophene-2-carboxylic acid
Smiles :
C[C@@H]1CC[C@H](CC1)C(=O)N([C@@H]1CC[C@@H](O)CC1)C1C=C(C#CC(C)(C)C)SC=1C(O)=O |&1:1,4,10,13|
InChiKey:
WPMJNLCLKAKMLA-VVPTUSLJSA-N
InChi :
InChI=1S/C25H35NO4S/c1-16-5-7-17(8-6-16)23(28)26(18-9-11-19(27)12-10-18)21-15-20(13-14-25(2,3)4)31-22(21)24(29)30/h15-19,27H,5-12H2,1-4H3,(H,29,30)/t16-,17-,18-,19-
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Spesolimab} medchemexpress|{Spesolimab} Interleukin Related|{Spesolimab} Purity & Documentation|{Spesolimab} In Vitro|{Spesolimab} supplier|{Spesolimab} Autophagy}
Shelf Life:
≥12 months if stored properly.{{Rituximab} web|{Rituximab} CD20|{Rituximab} Protocol|{Rituximab} In Vitro|{Rituximab} custom synthesis|{Rituximab} Epigenetics}
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
VX22, is an nonnucleoside NS5B polymerase inhibitor. VX-222 inhibits the 1b/Con1 HCV subgenomic replicon, with 50% effective concentrations (EC(50)s) 5 nM. VX-222 binds to the HCV polymerase with dissociation constants of 17 nM. In phase 1 and 2 clinical studies, VX-222 demonstrated effective antiviral efficacy, with substantial reductions in plasma HCV RNA in patients chronically infected with genotype 1 HCV.|Product information|CAS Number: 1026785-55-6|Molecular Weight: 445.61|Formula: C25H35NO4S|Synonym:|VCH-222|VX-22|Lomibuvir|Chemical Name: 5-(3, 3-dimethylbut-1-yn-1-yl)-3-((1r, 4R)-N-((1r, 4R)-4-hydroxycyclohexyl)-4-methylcyclohexane-1-carboxamido)thiophene-2-carboxylic acid|Smiles: C[C@@H]1CC[C@H](CC1)C(=O)N([C@@H]1CC[C@@H](O)CC1)C1C=C(C#CC(C)(C)C)SC=1C(O)=O |&1:1,4,10,13||InChiKey: WPMJNLCLKAKMLA-VVPTUSLJSA-N|InChi: InChI=1S/C25H35NO4S/c1-16-5-7-17(8-6-16)23(28)26(18-9-11-19(27)12-10-18)21-15-20(13-14-25(2,3)4)31-22(21)24(29)30/h15-19,27H,5-12H2,1-4H3,(H,29,30)/t16-,17-,18-,19-|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: Soluble in DMSO|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.PMID:23907051 |Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|
