Product Name :
NEP
Description:
NEP (VDP-green (NEP)) is a turn-on fluorescent probe based on the intramolecular charge transfer (ICT) mechanism for sensing vicinal dithiol-containing proteins (VDPs). NEP exhibits high selectivity toward VDPs in live cells and in vivo and displays a strong green fluorescence signal (λex/λem=430/535 nm). NEP has the potential for parkinsonism.
CAS:
2414276-32-5
Molecular Weight:
113.16
Formula:
C6H11NO
Chemical Name:
1-ethylpyrrolidin-2-one
Smiles :
CCN1CCCC1=O
InChiKey:
ZFPGARUNNKGOBB-UHFFFAOYSA-N
InChi :
InChI=1S/C6H11NO/c1-2-7-5-3-4-6(7)8/h2-5H2,1H3
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
NEP (VDP-green (NEP)) is a turn-on fluorescent probe based on the intramolecular charge transfer (ICT) mechanism for sensing vicinal dithiol-containing proteins (VDPs). NEP exhibits high selectivity toward VDPs in live cells and in vivo and displays a strong green fluorescence signal (λex/λem=430/535 nm). NEP has the potential for parkinsonism.|Product information|CAS Number: 2414276-32-5|Molecular Weight: 113.16|Formula: C6H11NO|Chemical Name: 1-ethylpyrrolidin-2-one|Smiles: CCN1CCCC1=O|InChiKey: ZFPGARUNNKGOBB-UHFFFAOYSA-N|InChi: InChI=1S/C6H11NO/c1-2-7-5-3-4-6(7)8/h2-5H2,1H3|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{NRG-1 Protein, Human} web|{NRG-1 Protein, Human} Biological Activity|{NRG-1 Protein, Human} In stock|{NRG-1 Protein, Human} manufacturer|{NRG-1 Protein, Human} Cancer} |Shelf Life: ≥12 months if stored properly.{{Selenomethionine} MedChemExpress|{Selenomethionine} Autophagy|{Selenomethionine} Purity & Documentation|{Selenomethionine} Description|{Selenomethionine} custom synthesis|{Selenomethionine} Epigenetic Reader Domain} |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.PMID:23962101 |Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|NEP (1-30 μM; 6 hours) has no or little cytotoxicity in HepG2 and PC12 cells. NEP (10 μM; 4 hours) causes the fluorescence intensity to decrease gradually in PC12 cells pretreated with 6-OHDA (0, 50, 100, and 200 μM; for 30 min). NEP contains a dithiarsolane moiety (five-membered As-S ring) as the receptor of VDPs. In the presence of VDPs, NEP displays a strong green fluorescence signal produced by the cyclic dithiarsolane cleavage and subsequent intramolecular cyclization to liberate the fluorophore. NEP maintains a reliable fluorescence response within the range of pH 7-10.|In Vivo:|NEP (10 μM; for 4 h) causes the obvious green signal in zebrafishes (4 day old).|Products are for research use only. Not for human use.|
