s of regular medicines becoming utilized to treat the viral infection by way of enhancing the immunity from the body (Vimalanathan et al. 2009; Lin et al. 2014; Ganjhu et al. 2015). Plants as a complete and via range of metabolites are helpful for therapeutic purposes, as an example, cessation of viral proliferations by regulating its adsorption, binding to host cell receptors, inhibition of fusion of virus into the host cell membrane and modulating intracellular signals (Khan et al. 2005; Ghosh et al. 2009). Similarly, the binding interaction among a pathogen protein and ligand derived from herbal extracts may well lead to inhibition of the activity of pathogen protein (Hiremath et al. 2021). Many in silico studies have been conducted (Narkhede et al. 2020; Pandit and Latha 2020; Srivastav et al. 2020; Joshi et al. 2020) for certain Rasayana herbs to explore their potential targets as pointed out in Table 1.Quest for precise treatment of nCoV infections is a challenge with changing strain of virus swiftly. The fast increase of persistent emerging new viral infections like COVID-19 poses a tremendous threat to mankind globally. Efficient tactics for prophylaxis and holistic management are of paramount importance. In the present understanding from the pandemic, it is actually well known that immunity has a pivotal role in prevention of the severity of such infections. Hence, preserving superior immunity needs to be taken as a prospective option for addressing such viral infection outbreaks (Hegde et al. 2009; Rijckborst et al. 2011). Herbs, which influence the immune system in specific or non-specific mode, is usually categorized below immuno-herbs which might be covered below the broad umbrella of Rasayana in Ayurveda (Doshi et al. 2013). These are getting studied to take care of vast array of ailments like infections, nonspecific fevers (van der Meijden 2001) and immune deficiency circumstances (Ziauddin et al. 1996). Right here, we describe the prospective role from the shortlisted Rasayana herbs against COVID-19.Justicia adhatoda L. (Adhatoda vasica Nees) (Vasa)Adhatoda vasica is well-known for its effectiveness in respiratory disorders, especially bronchitis and antitussive impact in Ayurveda (Dhuley 1999; Shrivastava et al. 2006). The alcoholic extract of A. vasica is α1β1 drug reported to reduce the count of neutrophils, therefore diminishing the phagocytosis activity. The extract was identified responsible to reduce in delayed-type hypersensitivity reactions and inhibitory effect on T lymphocytes as well as reported to possess human immunodeficiency virus (HIV) protease inhibitory activity (Singh et al. 2010; Vinothapooshan and Sundar 2011). The oral administration of aqueous extract in allergic and extreme asthmatic subtypes mouse model reports that A. vasica reduces elevated airway resistance and alleviates steroid (dexamethasone) resistance molecular signatures. These involve IL-17A, KC (murine IL-8 homologue) and hypoxiainducible factor-1 (HIF-1) by restoring expression of its negative regulator–prolyl hydroxylase domain-2 (PHD2) (Gheware et al. 2021b). In vivo research showed that elevated transforming development aspect (TGF)-1, IL-6 and HIF-1 in pulmonary fibrosis and sepsis rescues 5-HT2 Receptor Antagonist review siRNA-induced inflammation and modifies cellular hypoxic response and thrombosis (Gheware et al. 2021a). These studies figured out the potential function of A. vasica in inflammatory circumstances led in SARSCoV-2 and recommend a probable role in serious steroid-resistant asthma. The possible function of A. vasica is also suppor
