Ressed in striatal neurons [615], Ziritaxestat Purity targeted action improved therapeutic index. Recent studies on D1 R-mediated -arrestin have yielded several impressive clinical implications. Urs et al. reported that the D1 R-dependent, -arrestin-related ERK signal cascade impacted morphine-induced psychomotor activation but not reward [24,25], suggesting a separation of therapeutics (e.g., analgesic) from side effects (e.g., addiction). By analyzing transcriptional signatures in humans and mice, Labonte et al. reported that D1 R-mediated -arrestin signaling by means of ERK may impact sex-specific depression [68]. Several studies on ra.
