71) 0.48(0.26?.87) 6.45(4.67?.91) 1.26(0.81?.96) 3.43(2.42?.87) 1.89(1.17?.04) 0.85(0.69?.05) 0.88(0.66?.18) 1.31(0.70?.47) 1.28(0.67?.45) 1.04(0.47?.31) 1.27(0.55?.95) 0.79(0.62?.01) 0.84(0.63?.12) 0.74(0.57?.97) 0.74(0.52?.06) 0.9733 0.7515 0.3661 0.2878 0.0932 0.1596 0.0005 0.0162 <.0001 0.2978 <.0001 0.0089 0.1382 0.3886 0.4003 0.4587 0.9152 0.5745 0.0585 0.2294 0.0296 0.1024 0.74(0.67?.81) 0.46(0.41?.51) 1.02(0.90?.17) 0.55(0.50?.61) 0.92(0.71?.18) 1.42(1.03?.95) 1.16(0.78?.73) 1.33(0.81?.18) 1.63(1.13?.36) 1.43(0.86?.37) 1.43(0.86?.39) 1.22(0.70?.11) 2.45(1.56?.85) 1.18(0.71?.96) 3.64(2.24?.92) 1.14(0.65?.01) 0.1718 0.4863 0.1716 0.0098 0.2592 0.4734 0.37(0.21?.66) 0.99(0.49?.02) 0.26(0.13?.53) 0.98(0.40?.45) 0.0334 1.06(0.75?.51) 0.4919 0.53(0.41?.69) 1.08(0.94?.23) 0.48(0.39?.58) 0.98(0.76?.25) 0.53(0.43?.65) 1.04(0.79?.37) 0.88(0.77?.01) 0.83(0.71?.98) 0.93(0.82?.05) 0.68(0.58?.80) 0.91(0.78?.07) 0.57(0.47?.70) 1.00(0.86?.16) 0.57(0.46?.70) 4.24(3.78?.74) 1.61(1.39?.87) 2.75(2.44?.11) 1.00(0.82?.23) 0.53(0.40?.69) 0.77(0.66?.91) 0.86(0.67?.10) 1.05(0.67?.65) 0.83(0.52?.33) 1.21(0.70?.09) 0.84(0.46?.54) 1.10(0.89?.35) 1.11(0.87?.42) 1.20(0.97?.49) 0.4374 0.8233 0.2187 0.002order WP1066 ZM241385.html”>Trichostatin A site ZM241385MedChemExpress ZM241385 0 <.0001 0.9855 1.45(1.24?.71) 0.68(0.63?.74) 0.95(0.85?.07) 1.98(1.47?.67) 1.59(1.17?.16) 2.19(1.56?.07) 1.39(0.97?.99) 1.18(1.06?.32) 1.12(0.99?.26) 1.57(1.41?.76) 1.34(1.15?.55) 0.0001 <.0001 0.0766 0.0025 0.0743 <.0001 0.0032 <.0001 0.3945 <.0001 <.0001 <.0001 0.72(0.59?.89) 0.60(0.46?.77) 0.25(0.21?.29) <.0001 0.78(0.60?.00) 0.0525 0.81(0.66?.99) <.0001 1.13(0.93?.38) 0.2099 1.97(1.69?.31) <.0001 0.54(0.36?.81) 0.0030 1.08(0.73?.58) 0.7081 <.0001 0.9991 0.80(0.60?.06) 0.1225 5.18(3.88?.93) <.0001 <.0001 0.60(0.41?.88) 0.0084 0.83(0.56?.23) 0.3516 0.2391 0.80(0.59?.08) 0.1492 2.75(2.00?.78) <.0001 <.0001 0.69(0.52?.92) 0.0103 0.91(0.65?.28) 0.5823 0.2368 0.79(0.63?.00) 0.0459 1.75(1.31?.34) 0.0002 0.0241 0.78(0.57?.05) 0.1025 0.88(0.60?.29) 0.5239 0.0680 0.76(0.58?.99) 0.0442 0.96(0.68?.36) 0.8082 0.7804 0.81(0.47?.41) 0.4625 1.63(1.11?.39) 0.0119 <.0001 0.43(0.29?.65) 1.31(1.01?.70) 0.0447 <.0001 0.8451 0.55(0.31?.95) 0.0328 1.35(0.93?.97) 0.1181 <.0001 0.28(0.17?.45) 0.85(0.63?.14) 0.2677 <.0001 0.2987 0.80(0.61?.05) 0.1124 1.47(1.16?.86) 0.0014 <.0001 0.35(0.29?.44) 0.70(0.59?.84) <.0001 <.0001 0.7187 0.84(0.65?.09) 0.1902 1.12(0.88?.43) 0.3650 1.25(0.90?.74) 0.1811 1.07(0.78?.48) <.0001 0.36(0.29?.44) 0.37(0.30?.46) 0.53(0.40?.72) 0.50(0.39?.66) <.0001 <.0001 <.0001 <.0001 1.00(0.82?.22) 0.9857 0.82(0.69?.97) 0.0184 0.95(0.76?.18) 0.6212 0.77(0.60?.98) <.0001 1.04(0.88?.22) 0.6611 0.66(0.57?.76) 0.71(0.58?.86) 0.0005 0.83(0.67?.02) <.0001 0.3870 2.63(0.80?.61) 0.1114 1.15(0.15?.63) 0.8928 2.11(0.64?.99) 0.2227 0.1607 1.38(0.44?.35) 0.5872 0.31(0.04?.19) 0.2375 2.40(0.75?.61) 0.1385 0.98(0.24?.00) 1.22(0.28?.32) 1.03(0.87?.22) 0.98(0.80?.20) 0.27(0.21?.33) 1.10(0.86?.41) 0.24(0.19?.30) 0.93(0.71?.23) 0.19(0.11?.32) 0.68(0.38?.22) 0.14(0.07?.26) 0.53(0.26?.08) 0.67(0.50?.88) 0.69(0.50?.95) 0.76(0.60?.97) 0.70(0.52?.93) 0.89(0.65?.21) 0.61(0.42?.88) 0.96(0.72?.28) 0.64(0.44?.94) 3.14(2.53?.89) 0.91(0.70?.19) 1.96(1.54?.48) 0.90(0.66?.21) 1.10(0.92?.31) 1.47(1.15?.87) 1.54(0.88?.67) 1.58(0.89?.80) 1.51(0.78?.90) 1.50(0.74?.04) 1.10(0.89?.36) 1.16(0.91?.48) 1.23(0.98?.53) 1.38(1.02?.85) <.0001 0.98(0.77?.25) 0.8697 1.01(0.81?.27) 0.9039 1.40(1.06?.85) 0.0174 0.94(0.71?.25) 0.6795 0.90(0.71?.13) <.0001 0.81(0.67?.97) 0.0191 0.46(0.38?.56) 0.70(0.56?.87) 0.00.16 0.97(0.78?.21) 0.7997 0.81(0.67?.97) <.0001 <.0001 0.59(0.48?.73) 1.53(1.28?.83) 0.73(0.57?.92) 0.0085 16.26(10.75?4.59) 2.58(2.07?.22) <.0001 <.0001 <.0001 <.0001 0.0254 0.3524 0.9805 0.7901 0.7427 0.8228 <.0001 0.4628 <.0001 0.6287 <.0001 0.1959 <.0001 0.0800 0.0050 0.0217 0.0280 0.0131 0.4473 0.0080 0.7988 0.0227 <.0001 0.5019 <.0001 0.4701 0.2958 0.0019 0.1288 0.1213 0.2208 0.2620 0.3819 0.2219 0.0752 0.0362 <.0001 0.71(0.60?.84) 1.45(1.26?.67) 0.76(0.62?.92) 0.0056 13.11(8.91?9.29) 2.49(2.08?.99) <.0001 <.0001 <.0001 <.0001 <.0001 13.13(9.89?7.44) 12.40(8.86?7.35) 0.53(0.26?.08) 0.0824 <.0001 26.28(20.12?4.31) <.0001 <.0001 18.58(13.36?5.86) <.0001 <.0001 11.77(8.77?5.81) 0.46(0.24?.90) 0.0228 17.12(13.41?1.85) <.0001 28.74(22.76?6.29) <.0001 <.0001 21.29(15.96?8.41) <.0001 <.0001 4.80(3.79?.09) 6.82(5.29?.80) 0.95(0.72?.27) 0.7498 12.88(9.93?6.71) <.0001 12.86(10.29?6.07) <.0001 <.0001 <.0001 1.70(1.49?.95) 3.01(2.51?.60) 2.63(2.14?.22) 1.18(1.06?.30) 1.10(0.97?.25) 1.32(1.19?.47) 1.37(1.19?.57) 1.46(0.73?.93) 1.38(0.61?.14) 0.90(0.81?.00) 1.06(0.93?.21) 0.50(0.43?.57) 0.85(0.73?.01) 0.55(0.48?.63) 0.84(0.71?.99) 0.49(0.37?.66) 0.53(0.38?.75) 0.55(0.41?.74) 0.58(0.39?.85) 0.89(0.76?.04) 0.99(0.82?.20) 0.87(0.76?.00) 0.86(0.72?.02) 1.17(0.97?.41) 1.06(0.84?.35) 1.14(0.95?.37) 0.95(0.74?.22) 1.90(1.67?.16) 0.87(0.72?.05) 1.84(1.61?.10) 0.78(0.64?.95) 1.35(1.21?.50) 1.39(1.19?.63) 1.74(1.21?.51) 1.75(1.19?.58) 1.05(0.66?.69) 1.08(0.65?.80) 1.07(0.95?.21) 1.07(0.93?.24) 1.23(1.08?.41) 1.52(1.27?.83) <.0001 5.11(4.08?.40) 11.57(9.37?4.28) 6.59(5.18?.37) 0.83(0.64?.08) 0.1598 1.80(1.59?.03) <.0001 <.0001 <.0001 13.01(10.16?6.65) <.0001 <.0001 0.55(0.38?.81) 0.0021 0.02(<0.01?.11) 0.02(<0.01?.15) 0.0001 0.16(0.09?.29) 0.13(0.06?.29) 0.33(0.25?.42) <.0001 <.0001 <.0001 <.0001 <.0001 <.0001 <.0001 <.0001 0.0014 0.1302 <.0001 <.0001 0.2874 0.4396 0.0393 0.3630 <.0001 0.0569 <.0001 0.0416 <.0001 0.0003 0.0001 0.0053 0.1430 0.9135 0.0492 0.0889 0.0975 0.6239 0.1683 0.6801 <.0001 0.1416 <.0001 0.0151 <.0001 <.0001 0.0028 0.0045 0.8252 0.7595 0.2722 0.3302 0.0018 <.0001 <.0001 0.87(0.65?.17) 0.3613 0.03(0.01?.11) 0.03(0.01?.12) 0.12(0.08?.19) 0.15(0.07?.31) 0.39(0.33?.45) <.0001 <.0001 <.0001 <.0001 <.0001 0.53(0.47?.60) 0.52(0.43?.62) 2.54(2.30?.81) 2.34(2.10?.61) 5.02(4.35?.79) 4.25(3.61?.00) 1.11(1.03?.19) 1.07(0.96?.18) 0.76(0.70?.83) 0.98(0.87?.10) 0.47(0.22?.00) 0.58(0.23?.44) 0.89(0.82?.96) 0.96(0.87?.06) 0.63(0.57?.70) 0.96(0.84?.09) 0.82(0.74?.91) 0.98(0.86?.13) 0.88(0.73?.08) 0.76(0.59?.98) 1.32(1.09?.60) 0.85(0.65?.11) 1.19(1.05?.36) 1.25(1.06?.47) 1.32(1.18?.49) 1.15(0.98?.34) 1.86(1.60?.16) 1.41(1.16?.72) 2.78(2.42?.19) 1.54(1.26?.88) 1.64(1.49?.80) 0.90(0.78?.04) 1.14(1.03?.27) 0.78(0.67?.91) 0.62(0.57?.67) 0.87(0.77?.98) 0.89(0.72?.11) 0.83(0.64?.07) 2.11(1.64?.73) 1.16(0.84?.58) 1.13(1.02?.24) 0.92(0.81?.04) 2.14(1.94?.36) 1.38(1.19?.61) <.0001 0.07(0.01?.47) 0.0069 0.09(0.03?.27) 0.27(0.22?.34) <.0001 <.0001 p value OR (95 CI) p value OR (95 CI) p value OR (95 CI) p value OR (95 CI) p value OR (95 CI) p value OR (95 CI) p value OR (95 CI) 0.65(0.57?.74) COPD Hypertension Diabetes Mellitus Anemia Osteoarthritis Moderate Severe p value <.0001 <.0001 <.0001 <.0001 <.0001 <.0001 <.0001 0.0090 0.2139 <.0001 0.6786 0.0513 0.2396 0.0017 0.4100 <.0001 0.4963 0.0002 0.8158 0.2180 0.0308 0.0054 0.2313 0.0088 0.0072 <.0001 0.0853 <.0001 0.0007 <.0001 <.0001 <.0001 0.1514 0.0105 0.0017 <.0001 0.0231 0.2944 0.1451 <.0001 0.3729 0.0158 0.16 0.97(0.78?.21) 0.7997 0.81(0.67?.97) <.0001 <.0001 0.59(0.48?.73) 1.53(1.28?.83) 0.73(0.57?.92) 0.0085 16.26(10.75?4.59) 2.58(2.07?.22) <.0001 <.0001 <.0001 <.0001 0.0254 0.3524 0.9805 0.7901 0.7427 0.8228 <.0001 0.4628 <.0001 0.6287 <.0001 0.1959 <.0001 0.0800 0.0050 0.0217 0.0280 0.0131 0.4473 0.0080 0.7988 0.0227 <.0001 0.5019 <.0001 0.4701 0.2958 0.0019 0.1288 0.1213 0.2208 0.2620 0.3819 0.2219 0.0752 0.0362 <.0001 0.71(0.60?.84) 1.45(1.26?.67) 0.76(0.62?.92) 0.0056 13.11(8.91?9.29) 2.49(2.08?.99) <.0001 <.0001 <.0001 <.0001 <.0001 13.13(9.89?7.44) 12.40(8.86?7.35) 0.53(0.26?.08) 0.0824 <.0001 26.28(20.12?4.31) <.0001 <.0001 18.58(13.36?5.86) <.0001 <.0001 11.77(8.77?5.81) 0.46(0.24?.90) 0.0228 17.12(13.41?1.85) <.0001 28.74(22.76?6.29) <.0001 <.0001 21.29(15.96?8.41) <.0001 <.0001 4.80(3.79?.09) 6.82(5.29?.80) 0.95(0.72?.27) 0.7498 12.88(9.93?6.71) <.0001 12.86(10.29?6.07) <.0001 <.0001 <.0001 1.70(1.49?.95) 3.01(2.51?.60) 2.63(2.14?.22) 1.18(1.06?.30) 1.10(0.97?.25) 1.32(1.19?.47) 1.37(1.19?.57) 1.46(0.73?.93) 1.38(0.61?.14) 0.90(0.81?.00) 1.06(0.93?.21) 0.50(0.43?.57) 0.85(0.73?.01) 0.55(0.48?.63) 0.84(0.71?.99) 0.49(0.37?.66) 0.53(0.38?.75) 0.55(0.41?.74) 0.58(0.39?.85) 0.89(0.76?.04) 0.99(0.82?.20) 0.87(0.76?.00) 0.86(0.72?.02) 1.17(0.97?.41) 1.06(0.84?.35) 1.14(0.95?.37) 0.95(0.74?.22) 1.90(1.67?.16) 0.87(0.72?.05) 1.84(1.61?.10) 0.78(0.64?.95) 1.35(1.21?.50) 1.39(1.19?.63) 1.74(1.21?.51) 1.75(1.19?.58) 1.05(0.66?.69) 1.08(0.65?.80) 1.07(0.95?.21) 1.07(0.93?.24) 1.23(1.08?.41) 1.52(1.27?.83) <.0001 5.11(4.08?.40) 11.57(9.37?4.28) 6.59(5.18?.37) 0.83(0.64?.08) 0.1598 1.80(1.59?.03) <.0001 <.0001 <.0001 13.01(10.16?6.65) <.0001 <.0001 0.55(0.38?.81) 0.0021 0.02(<0.01?.11) 0.02(<0.01?.15) 0.0001 0.16(0.09?.29) 0.13(0.06?.29) 0.33(0.25?.42) <.0001 <.0001 <.0001 <.0001 <.0001 <.0001 <.0001 <.0001 0.0014 0.1302 <.0001 <.0001 0.2874 0.4396 0.0393 0.3630 <.0001 0.0569 <.0001 0.0416 <.0001 0.0003 0.0001 0.0053 0.1430 0.9135 0.0492 0.0889 0.0975 0.6239 0.1683 0.6801 <.0001 0.1416 <.0001 0.0151 <.0001 <.0001 0.0028 0.0045 0.8252 0.7595 0.2722 0.3302 0.0018 <.0001 <.0001 0.87(0.65?.17) 0.3613 0.03(0.01?.11) 0.03(0.01?.12) 0.12(0.08?.19) 0.15(0.07?.31) 0.39(0.33?.45) <.0001 <.0001 <.0001 <.0001 <.0001 0.53(0.47?.60) 0.52(0.43?.62) 2.54(2.30?.81) 2.34(2.10?.61) 5.02(4.35?.79) 4.25(3.61?.00) 1.11(1.03?.19) 1.07(0.96?.18) 0.76(0.70?.83) 0.98(0.87?.10) 0.47(0.22?.00) 0.58(0.23?.44) 0.89(0.82?.96) 0.96(0.87?.06) 0.63(0.57?.70) 0.96(0.84?.09) 0.82(0.74?.91) 0.98(0.86?.13) 0.88(0.73?.08) 0.76(0.59?.98) 1.32(1.09?.60) 0.85(0.65?.11) 1.19(1.05?.36) 1.25(1.06?.47) 1.32(1.18?.49) 1.15(0.98?.34) 1.86(1.60?.16) 1.41(1.16?.72) 2.78(2.42?.19) 1.54(1.26?.88) 1.64(1.49?.80) 0.90(0.78?.04) 1.14(1.03?.27) 0.78(0.67?.91) 0.62(0.57?.67) 0.87(0.77?.98) 0.89(0.72?.11) 0.83(0.64?.07) 2.11(1.64?.73) 1.16(0.84?.58) 1.13(1.02?.24) 0.92(0.81?.04) 2.14(1.94?.36) 1.38(1.19?.61) <.0001 0.07(0.01?.47) 0.0069 0.09(0.03?.27) 0.27(0.22?.34) <.0001 <.0001 p value OR (95 CI) p value OR (95 CI) p value OR (95 CI) p value OR (95 CI) p value OR (95 CI) p value OR (95 CI) p value OR (95 CI) 0.65(0.57?.74) COPD Hypertension Diabetes Mellitus Anemia Osteoarthritis Moderate Severe p value <.0001 <.0001 <.0001 <.0001 <.0001 <.0001 <.0001 0.0090 0.2139 <.0001 0.6786 0.0513 0.2396 0.0017 0.4100 <.0001 0.4963 0.0002 0.8158 0.2180 0.0308 0.0054 0.2313 0.0088 0.0072 <.0001 0.0853 <.0001 0.0007 <.0001 <.0001 <.0001 0.1514 0.0105 0.0017 <.0001 0.0231 0.2944 0.1451 <.0001 0.3729 0.0158 0.
