Product Name :
E-7386
Description:
E-7386 is an orally active CBP/beta-catenin modulator.
CAS:
1799824-08-0
Molecular Weight:
725.85
Formula:
C39H48FN9O4
Chemical Name:
(6S,9aS)-N-benzyl-8-(6-[3-(4-ethylpiperazin-1-yl)azetidin-1-yl]pyridin-2-ylmethyl)-6-[(2-fluoro-4-hydroxyphenyl)methyl]-9a-hydrogenio-4,7-dioxo-2-(prop-2-en-1-yl)-octahydro-1H-pyrazino[2,1-c][1,2,4]triazine-1-carboxamide
Smiles :
CCN1CCN(CC1)C1CN(C1)C1=CC=CC(CN2C[C@H]3N([C@@H](CC4=CC=C(O)C=C4F)C2=O)C(=O)CN(CC=C)N3C(=O)NCC2C=CC=CC=2)=N1
InChiKey:
ZGNKNLOBYFTGRG-GIWKVKTRSA-N
InChi :
InChI=1S/C39H48FN9O4/c1-3-15-47-27-37(51)48-34(20-29-13-14-32(50)21-33(29)40)38(52)46(26-36(48)49(47)39(53)41-22-28-9-6-5-7-10-28)23-30-11-8-12-35(42-30)45-24-31(25-45)44-18-16-43(4-2)17-19-44/h3,5-14,21,31,34,36,50H,1,4,15-20,22-27H2,2H3,(H,41,53)/t34-,36-/m0/s1
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
E-7386 is an orally active CBP/beta-catenin modulator.|Product information|CAS Number: 1799824-08-0|Molecular Weight: 725.85|Formula: C39H48FN9O4|Chemical Name: (6S,9aS)-N-benzyl-8-(6-[3-(4-ethylpiperazin-1-yl)azetidin-1-yl]pyridin-2-ylmethyl)-6-[(2-fluoro-4-hydroxyphenyl)methyl]-9a-hydrogenio-4,7-dioxo-2-(prop-2-en-1-yl)-octahydro-1H-pyrazino[2,1-c][1,2,4]triazine-1-carboxamide|Smiles: CCN1CCN(CC1)C1CN(C1)C1=CC=CC(CN2C[C@H]3N([C@@H](CC4=CC=C(O)C=C4F)C2=O)C(=O)CN(CC=C)N3C(=O)NCC2C=CC=CC=2)=N1|InChiKey: ZGNKNLOBYFTGRG-GIWKVKTRSA-N|InChi: InChI=1S/C39H48FN9O4/c1-3-15-47-27-37(51)48-34(20-29-13-14-32(50)21-33(29)40)38(52)46(26-36(48)49(47)39(53)41-22-28-9-6-5-7-10-28)23-30-11-8-12-35(42-30)45-24-31(25-45)44-18-16-43(4-2)17-19-44/h3,5-14,21,31,34,36,50H,1,4,15-20,22-27H2,2H3,(H,41,53)/t34-,36-/m0/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : 125 mg/mL (172.CGS 21680 custom synthesis 21 mM; Need ultrasonic).Metyrapone Autophagy |Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.PMID:32750876 |Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vivo:|E-7386 is an orally active CBP/beta-catenin modulator which can induce T cells infiltration into tumor and enhance antitumor activity of anti-PD-1 mAb in Wnt1 tumor syngeneic mice model. E-7386 shows significant antitumor activity in Wnt1 model. Infiltration of T cells is limited in vehicle control group, but T cell infiltration into tumors is clearly observed in E-7386 treatment group.|Products are for research use only. Not for human use.|
