Product Name :
Dorzagliatin
Description:
Dorzagliatin (HMS5552), a dual-acting glucokinase (GK) activator, improves glycaemic control and pancreatic β-cell function in type 2 diabetes.
CAS:
1191995-00-2
Molecular Weight:
462.93
Formula:
C22H27ClN4O5
Chemical Name:
(2S)-2-[4-(2-chlorophenoxy)-2-oxo-2,5-dihydro-1H-pyrrol-1-yl]-N-{1-[(2R)-2,3-dihydroxypropyl]-1H-pyrazol-3-yl}-4-methylpentanamide
Smiles :
CC(C)C[C@@H](C(=O)NC1C=CN(C[C@@H](O)CO)N=1)N1CC(=CC1=O)OC1=CC=CC=C1Cl
InChiKey:
HMUMWSORCUWQJO-QAPCUYQASA-N
InChi :
InChI=1S/C22H27ClN4O5/c1-14(2)9-18(22(31)24-20-7-8-26(25-20)11-15(29)13-28)27-12-16(10-21(27)30)32-19-6-4-3-5-17(19)23/h3-8,10,14-15,18,28-29H,9,11-13H2,1-2H3,(H,24,25,31)/t15-,18+/m1/s1
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
Dorzagliatin (HMS5552), a dual-acting glucokinase (GK) activator, improves glycaemic control and pancreatic β-cell function in type 2 diabetes.|Product information|CAS Number: 1191995-00-2|Molecular Weight: 462.93|Formula: C22H27ClN4O5|Chemical Name: (2S)-2-[4-(2-chlorophenoxy)-2-oxo-2,5-dihydro-1H-pyrrol-1-yl]-N-{1-[(2R)-2,3-dihydroxypropyl]-1H-pyrazol-3-yl}-4-methylpentanamide|Smiles: CC(C)C[C@@H](C(=O)NC1C=CN(C[C@@H](O)CO)N=1)N1CC(=CC1=O)OC1=CC=CC=C1Cl|InChiKey: HMUMWSORCUWQJO-QAPCUYQASA-N|InChi: InChI=1S/C22H27ClN4O5/c1-14(2)9-18(22(31)24-20-7-8-26(25-20)11-15(29)13-28)27-12-16(10-21(27)30)32-19-6-4-3-5-17(19)23/h3-8,10,14-15,18,28-29H,9,11-13H2,1-2H3,(H,24,25,31)/t15-,18+/m1/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : 125 mg/mL (270.{{Enzalutamide} medchemexpress|{Enzalutamide} Autophagy|{Enzalutamide} Purity & Documentation|{Enzalutamide} References|{Enzalutamide} supplier|{Enzalutamide} Autophagy} 02 mM; Need ultrasonic).{{α-MSH} site|{α-MSH} Neuronal Signaling|{α-MSH} NF-κB|{α-MSH} Technical Information|{α-MSH} In Vivo|{α-MSH} manufacturer} |Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.PMID:32354629 |Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vivo:|Dorzagliatin (low-dose 10 mg/kg, and high-dose 30 mg/kg; administered intragastrically; daily 8:00 AM for one month) exerts a glucose-lowering effect on the glucose levels in diabetic rats[2.|Products are for research use only. Not for human use.|
