Product Name :
UK-157147
Description:
UK-157147 is a substrate for UDP-glucuronosyltransferases (UGT1A1) with a Km value of 105 μM.
CAS:
162704-20-3
Molecular Weight:
472.51
Formula:
C23H24N2O7S
Chemical Name:
6-{[(3S,4R)-3-hydroxy-6-(3-hydroxybenzenesulfonyl)-2,2,3-trimethyl-3,4-dihydro-2H-1-benzopyran-4-yl]oxy}-2-methyl-2,3-dihydropyridazin-3-one
Smiles :
CC1(C)OC2=CC=C(C=C2[C@@H](OC2C=CC(=O)N(C)N=2)[C@]1(C)O)S(=O)(=O)C1=CC=CC(O)=C1
InChiKey:
MOZBVDKKWDXRGH-GGAORHGYSA-N
InChi :
InChI=1S/C23H24N2O7S/c1-22(2)23(3,28)21(31-19-10-11-20(27)25(4)24-19)17-13-16(8-9-18(17)32-22)33(29,30)15-7-5-6-14(26)12-15/h5-13,21,26,28H,1-4H3/t21-,23+/m1/s1
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Diquafosol tetrasodium} MedChemExpress|{Diquafosol tetrasodium} P2Y Receptor|{Diquafosol tetrasodium} Technical Information|{Diquafosol tetrasodium} References|{Diquafosol tetrasodium} manufacturer|{Diquafosol tetrasodium} Autophagy}
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
UK-157147 is a substrate for UDP-glucuronosyltransferases (UGT1A1) with a Km value of 105 μM.|Product information|CAS Number: 162704-20-3|Molecular Weight: 472.51|Formula: C23H24N2O7S|Chemical Name: 6-{[(3S,4R)-3-hydroxy-6-(3-hydroxybenzenesulfonyl)-2,2,3-trimethyl-3,4-dihydro-2H-1-benzopyran-4-yl]oxy}-2-methyl-2,3-dihydropyridazin-3-one|Smiles: CC1(C)OC2=CC=C(C=C2[C@@H](OC2C=CC(=O)N(C)N=2)[C@]1(C)O)S(=O)(=O)C1=CC=CC(O)=C1|InChiKey: MOZBVDKKWDXRGH-GGAORHGYSA-N|InChi: InChI=1S/C23H24N2O7S/c1-22(2)23(3,28)21(31-19-10-11-20(27)25(4)24-19)17-13-16(8-9-18(17)32-22)33(29,30)15-7-5-6-14(26)12-15/h5-13,21,26,28H,1-4H3/t21-,23+/m1/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Dasatinib} web|{Dasatinib} Autophagy|{Dasatinib} Technical Information|{Dasatinib} In Vivo|{Dasatinib} supplier|{Dasatinib} Autophagy} |Shelf Life: ≥12 months if stored properly.PMID:32393069 |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|Glucuronidation is an important pathway for human drug metabolism. Four cloned and expressed human UDP-glucuronosyltransferases (UGT1A1, UGT1A6, UGT1A9, and UGT2B15) are used to screen a series of three potential drug substrates differing only in position of the phenol moiety. The para phenol UK-157147 (UK-157,147) is found to be a substrate for UGT1A1 with a Km value of 105 μM.|Products are for research use only. Not for human use.|
