Product Name :
JWG-071
Description:
JWG-071 is the first reported kinase-selective chemical probe for ERK5. JWG-071 improves ERK5 activity and BRD4 selectivity. JWG-071 will be a much-needed chemical probe for deconvoluting ERK5 and BRD4 pharmacology.
CAS:
2250323-50-1
Molecular Weight:
612.76
Formula:
C34H44N8O3
Chemical Name:
2-(butan-2-yl)-5-({2-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidine-1-carbonyl]phenyl}amino)-9-methyl-2, 4, 6, 9-tetraazatricyclo[9.4.0.0, ]pentadeca-1(15), 3, 5, 7, 11, 13-hexaen-10-one
Smiles :
CC(CC)N1C2=NC(NC3=CC=C(C=C3OC)C(=O)N3CCC(CC3)N3CCN(C)CC3)=NC=C2N(C)C(=O)C2=CC=CC=C12
InChiKey:
ACWOMSOYIIVIRV-UHFFFAOYSA-N
InChi :
InChI=1S/C34H44N8O3/c1-6-23(2)42-28-10-8-7-9-26(28)33(44)39(4)29-22-35-34(37-31(29)42)36-27-12-11-24(21-30(27)45-5)32(43)41-15-13-25(14-16-41)40-19-17-38(3)18-20-40/h7-12,21-23,25H,6,13-20H2,1-5H3,(H,35,36,37)
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥360 days if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
JWG-071 is the first reported kinase-selective chemical probe for ERK5. JWG-071 improves ERK5 activity and BRD4 selectivity. JWG-071 will be a much-needed chemical probe for deconvoluting ERK5 and BRD4 pharmacology.|Product information|CAS Number: 2250323-50-1|Molecular Weight: 612.76|Formula: C34H44N8O3|Chemical Name: 2-(butan-2-yl)-5-({2-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidine-1-carbonyl]phenyl}amino)-9-methyl-2, 4, 6, 9-tetraazatricyclo[9.4.0.0, ]pentadeca-1(15), 3, 5, 7, 11, 13-hexaen-10-one|Smiles: CC(CC)N1C2=NC(NC3=CC=C(C=C3OC)C(=O)N3CCC(CC3)N3CCN(C)CC3)=NC=C2N(C)C(=O)C2=CC=CC=C12|InChiKey: ACWOMSOYIIVIRV-UHFFFAOYSA-N|InChi: InChI=1S/C34H44N8O3/c1-6-23(2)42-28-10-8-7-9-26(28)33(44)39(4)29-22-35-34(37-31(29)42)36-27-12-11-24(21-30(27)45-5)32(43)41-15-13-25(14-16-41)40-19-17-38(3)18-20-40/h7-12,21-23,25H,6,13-20H2,1-5H3,(H,35,36,37)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: Soluble in DMSO.{{Amivantamab} web|{Amivantamab} EGFR|{Amivantamab} Technical Information|{Amivantamab} In Vivo|{Amivantamab} supplier|{Amivantamab} Epigenetics} |Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Amiloride hydrochloride dihydrate} MedChemExpress|{Amiloride hydrochloride dihydrate} Membrane Transporter/Ion Channel|{Amiloride hydrochloride dihydrate} NF-κB|{Amiloride hydrochloride dihydrate} Technical Information|{Amiloride hydrochloride dihydrate} References|{Amiloride hydrochloride dihydrate} custom synthesis} |Shelf Life: ≥360 days if stored properly.PMID:32048895 |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|JWG-071 inhibits ERK5 and LRRK2 with IC50 of 88 and 109 nM, respectively.|References:| Wang J, et al. Structural and Atropisomeric Factors Governing the Selectivity of Pyrimido-benzodiazipinonesas Inhibitors of Kinases and Bromodomains. ACS Chem Biol. 2018 Sep 21;13(9):2438-2448 Products are for research use only. Not for human use.|
