Product Name :
Rp-cAMPS triethylammonium salt
Description:
Rp-cAMPS triethylammonium salt, a cAMP analog, is a potent, competitive cAMP-induced activation of cAMP-dependent PKA I and II (Kis of 12.5 µM and 4.5 µM, respectively) antagonist. Rp-cAMPS triethylammonium salt is resistant to hydrolysis by phosphodiesterases.
CAS:
151837-09-1
Molecular Weight:
446.46
Formula:
C16H27N6O5PS
Chemical Name:
(2R, 4aR, 6R, 7R, 7aS)-6-(6-amino-9H-purin-9-yl)-7-hydroxy-2-sulfanyl-hexahydro-2-furo[3, 2-d][1, 3, 2]dioxaphosphinin-2-one; triethylamine
Smiles :
CCN(CC)CC.NC1=NC=NC2=C1N=CN2[C@@H]1O[C@@H]2CO[P@@](=O)(S)O[C@H]2[C@H]1O
InChiKey:
OXIPZMKSNMRTIV-RNSTXJOVSA-N
InChi :
InChI=1S/C10H12N5O5PS.C6H15N/c11-8-5-9(13-2-12-8)15(3-14-5)10-6(16)7-4(19-10)1-18-21(17,22)20-7;1-4-7(5-2)6-3/h2-4,6-7,10,16H,1H2,(H,17,22)(H2,11,12,13);4-6H2,1-3H3/t4-,6-,7-,10-,21-;/m1./s1
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥360 days if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.{{ARRY-382} site|{ARRY-382} Protein Tyrosine Kinase/RTK|{ARRY-382} Activator|{ARRY-382} Technical Information|{ARRY-382} Formula|{ARRY-382} custom synthesis}
Additional information:
Rp-cAMPS triethylammonium salt, a cAMP analog, is a potent, competitive cAMP-induced activation of cAMP-dependent PKA I and II (Kis of 12.{{Obeticholic acid} MedChemExpress|{Obeticholic acid} Metabolic Enzyme/Protease|{Obeticholic acid} Technical Information|{Obeticholic acid} Description|{Obeticholic acid} supplier|{Obeticholic acid} Epigenetics} 5 µM and 4.5 µM, respectively) antagonist. Rp-cAMPS triethylammonium salt is resistant to hydrolysis by phosphodiesterases.|Product information|CAS Number: 151837-09-1|Molecular Weight: 446.46|Formula: C16H27N6O5PS|Chemical Name: (2R, 4aR, 6R, 7R, 7aS)-6-(6-amino-9H-purin-9-yl)-7-hydroxy-2-sulfanyl-hexahydro-2-furo[3, 2-d][1, 3, 2]dioxaphosphinin-2-one; triethylamine|Smiles: CCN(CC)CC.NC1=NC=NC2=C1N=CN2[C@@H]1O[C@@H]2CO[P@@](=O)(S)O[C@H]2[C@H]1O|InChiKey: OXIPZMKSNMRTIV-RNSTXJOVSA-N|InChi: InChI=1S/C10H12N5O5PS.C6H15N/c11-8-5-9(13-2-12-8)15(3-14-5)10-6(16)7-4(19-10)1-18-21(17,22)20-7;1-4-7(5-2)6-3/h2-4,6-7,10,16H,1H2,(H,17,22)(H2,11,12,13);4-6H2,1-3H3/t4-,6-,7-,10-,21-;/m1./s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: Soluble in DMSO.PMID:31536295 |Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥360 days if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|A membrane-permeable competitive cAMP antagonist (Rp-cAMPS) that blocks PKA activation by binding to the regulatory subunits without dissociating the kinase holoenzyme also inhibits synaptic plasticity but has no effect on normal synaptic transmission.|In Vivo:|Rp-cAMPS (10 μM, 15 min) decreases the monosynaptic EPSCs evoked at the PB-CeLC and BLA-CeLC synapses in slices from arthritic rats but not in control neurons from normal animals. The inhibitory effect of Rp-cAMPS is significant compared to predrug (ACSF) control values obtained in the same neurons.|References:|R J de Wit, et al. Inhibitory action of certain cyclophosphate derivatives of cAMP on cAMP-dependent protein kinases. Eur J Biochem. 1984 Jul 16;142(2):255-60.Rothermel JD, et al. A mechanistic and kinetic analysis of the interactions of the diastereoisomers of adenosine 3′,5′-(cyclic)phosphorothioate with purified cyclic AMP-dependent protein kinase. Biochem J. 1988 May 1;251(3):757-62.Products are for research use only. Not for human use.|
