Product Name :
CK2/ERK8-IN-1
Description:
CK2/ERK8-IN-1 is a dual casein kinase 2 (CK2) (Ki of 0.25 µM) and ERK8 (MAPK15, ERK7) inhibitor with IC50s of 0.50 μM. CK2/ERK8-IN-1 also binds to PIM1, HIPK2 (homeodomain-interacting protein kinase 2), and DYRK1A with Kis of 8.65 µM, 15.25 µM, and 11.9 µM, respectively. CK2/ERK8-IN-1 has pro-apoptotic efficacy.
CAS:
1085822-09-8
Molecular Weight:
534.82
Formula:
C11H9Br4N3O2
Chemical Name:
2-[4, 5, 6, 7-tetrabromo-2-(dimethylamino)-1H-1, 3-benzodiazol-1-yl]acetic acid
Smiles :
CN(C)C1=NC2=C(C(Br)=C(Br)C(Br)=C2Br)N1CC(O)=O
InChiKey:
PHAOTASRLQMKBE-UHFFFAOYSA-N
InChi :
InChI=1S/C11H9Br4N3O2/c1-17(2)11-16-9-7(14)5(12)6(13)8(15)10(9)18(11)3-4(19)20/h3H2,1-2H3,(H,19,20)
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Obeticholic acid} medchemexpress|{Obeticholic acid} FXR|{Obeticholic acid} Technical Information|{Obeticholic acid} Description|{Obeticholic acid} manufacturer|{Obeticholic acid} Epigenetic Reader Domain}
Shelf Life:
≥360 days if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
CK2/ERK8-IN-1 is a dual casein kinase 2 (CK2) (Ki of 0.25 µM) and ERK8 (MAPK15, ERK7) inhibitor with IC50s of 0.50 μM. CK2/ERK8-IN-1 also binds to PIM1, HIPK2 (homeodomain-interacting protein kinase 2), and DYRK1A with Kis of 8.65 µM, 15.25 µM, and 11.9 µM, respectively. CK2/ERK8-IN-1 has pro-apoptotic efficacy.|Product information|CAS Number: 1085822-09-8|Molecular Weight: 534.{{Amiodarone} MedChemExpress|{Amiodarone} Potassium Channel|{Amiodarone} Technical Information|{Amiodarone} Description|{Amiodarone} custom synthesis|{Amiodarone} Epigenetics} 82|Formula: C11H9Br4N3O2|Chemical Name: 2-[4, 5, 6, 7-tetrabromo-2-(dimethylamino)-1H-1, 3-benzodiazol-1-yl]acetic acid|Smiles: CN(C)C1=NC2=C(C(Br)=C(Br)C(Br)=C2Br)N1CC(O)=O|InChiKey: PHAOTASRLQMKBE-UHFFFAOYSA-N|InChi: InChI=1S/C11H9Br4N3O2/c1-17(2)11-16-9-7(14)5(12)6(13)8(15)10(9)18(11)3-4(19)20/h3H2,1-2H3,(H,19,20)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : 16.PMID:32844719 67 mg/mL (31.17 mM; Need ultrasonic)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥360 days if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|CK2/ERK8-IN-1 (Compound K66; 0-50 µM; 24 hours; Jurkat cells) treatment displays cytotoxic activity in Jurkat cells.|References:|Pagano MA, et al. The selectivity of inhibitors of protein kinase CK2: an update. Biochem J. 2008 Nov 1;415(3):353-65.Products are for research use only. Not for human use.|
