Product Name :
A 412997 dihydrochloride
Description:
A 412997 dihydrochloride is a selective agonist of dopamine D4 receptor with Ki values of 7.9 and 12.1 nM for human and rat D4 receptors, respectively . Dopamine D4 receptor is a G protein-coupled receptor and is activated by dopamine. It plays an important role in cognition, Parkinsons disease, addictive behaviors and so on. A 412997 dihydrochloride is a selective dopamine D4 receptor agonist. In calcium flux functional assays, A-412997 activated the rat dopamine D4 receptor with EC50 value and intrinsic activity of 28.4 nM and 0.83, respectively . In Spontaneous Hypertensive Rat pups (SHR pups), A 412997 significantly increased acquisition in the 5-trial repeated acquisition model. In the short-term social memory, A 412997 significantly shortened the second investigation time. In Wistar rats and Dawley rats, A 412997 (3 μM/kg, 10 μM/kg) increased locomotor activity . In rats, A 412997 reduced non-rapid eye movement (NREM) sleep duration and increased waking duration. Also, A 412997 reduced rapid eye movement (REM) sleep duration and delayed the onset of REM sleep .
CAS:
1347744-96-0
Molecular Weight:
382.33
Formula:
C19H25Cl2N3O
Chemical Name:
(Z)-N-(3-methylphenyl)-2-[4-(pyridin-2-yl)piperidin-1-yl]ethanimidic acid dihydrochloride
Smiles :
Cl.Cl.CC1=CC(=CC=C1)/N=C(\O)/CN1CCC(CC1)C1=CC=CC=N1
InChiKey:
KIGNSSHMCNBHQX-UHFFFAOYSA-N
InChi :
InChI=1S/C19H23N3O.2ClH/c1-15-5-4-6-17(13-15)21-19(23)14-22-11-8-16(9-12-22)18-7-2-3-10-20-18;;/h2-7,10,13,16H,8-9,11-12,14H2,1H3,(H,21,23);2*1H
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
A 412997 dihydrochloride is a selective agonist of dopamine D4 receptor with Ki values of 7.9 and 12.1 nM for human and rat D4 receptors, respectively . Dopamine D4 receptor is a G protein-coupled receptor and is activated by dopamine. It plays an important role in cognition, Parkinsons disease, addictive behaviors and so on. A 412997 dihydrochloride is a selective dopamine D4 receptor agonist. In calcium flux functional assays, A-412997 activated the rat dopamine D4 receptor with EC50 value and intrinsic activity of 28.4 nM and 0.83, respectively . In Spontaneous Hypertensive Rat pups (SHR pups), A 412997 significantly increased acquisition in the 5-trial repeated acquisition model. In the short-term social memory, A 412997 significantly shortened the second investigation time. In Wistar rats and Dawley rats, A 412997 (3 μM/kg, 10 μM/kg) increased locomotor activity . In rats, A 412997 reduced non-rapid eye movement (NREM) sleep duration and increased waking duration. Also, A 412997 reduced rapid eye movement (REM) sleep duration and delayed the onset of REM sleep .{{Sodium metatungstate} MedChemExpress|{Sodium metatungstate} Interleukin Related|{Sodium metatungstate} Epigenetics|{Sodium metatungstate} Technical Information|{Sodium metatungstate} Description|{Sodium metatungstate} custom synthesis} |Product information|CAS Number: 1347744-96-0|Molecular Weight: 382.{{Alirocumab} web|{Alirocumab} PCSK9|{Alirocumab} Purity & Documentation|{Alirocumab} Purity|{Alirocumab} custom synthesis|{Alirocumab} Epigenetic Reader Domain} 33|Formula: C19H25Cl2N3O|Chemical Name: (Z)-N-(3-methylphenyl)-2-[4-(pyridin-2-yl)piperidin-1-yl]ethanimidic acid dihydrochloride|Smiles: Cl.PMID:27108903 Cl.CC1=CC(=CC=C1)/N=C(\O)/CN1CCC(CC1)C1=CC=CC=N1|InChiKey: KIGNSSHMCNBHQX-UHFFFAOYSA-N|InChi: InChI=1S/C19H23N3O.2ClH/c1-15-5-4-6-17(13-15)21-19(23)14-22-11-8-16(9-12-22)18-7-2-3-10-20-18;;/h2-7,10,13,16H,8-9,11-12,14H2,1H3,(H,21,23);2*1H|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|
