Product Name :
SB228357
Description:
SB228357 is a selective, potent and orall active 5-HT2C/2B receptor antagonist with pKi values of 6.9, 8.0 and 9.0 for 5-HT2A, 5-HT2B and 5-HT2C, respectively. SB228357 has antidepressant/anxiolytic effects.
CAS:
181629-93-6
Molecular Weight:
431.38
Formula:
C22H17F4N3O2
Chemical Name:
N-[3-fluoro-5-(pyridin-3-yl)phenyl]-5-methoxy-6-(trifluoromethyl)-2,3-dihydro-1H-indole-1-carboxamide
Smiles :
COC1=CC2CCN(C(=O)NC3=CC(F)=CC(=C3)C3C=NC=CC=3)C=2C=C1C(F)(F)F
InChiKey:
RRJLJKRFFRZRAF-UHFFFAOYSA-N
InChi :
InChI=1S/C22H17F4N3O2/c1-31-20-9-13-4-6-29(19(13)11-18(20)22(24,25)26)21(30)28-17-8-15(7-16(23)10-17)14-3-2-5-27-12-14/h2-3,5,7-12H,4,6H2,1H3,(H,28,30)
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Ketoprofen} site|{Ketoprofen} COX|{Ketoprofen} Protocol|{Ketoprofen} In stock|{Ketoprofen} custom synthesis|{Ketoprofen} Autophagy}
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
SB228357 is a selective, potent and orall active 5-HT2C/2B receptor antagonist with pKi values of 6.{{Prodan} medchemexpress|{Prodan} {Fluorescent Dye}|{Prodan} Technical Information|{Prodan} Description|{Prodan} manufacturer|{Prodan} Cancer} 9, 8.0 and 9.0 for 5-HT2A, 5-HT2B and 5-HT2C, respectively. SB228357 has antidepressant/anxiolytic effects.|Product information|CAS Number: 181629-93-6|Molecular Weight: 431.38|Formula: C22H17F4N3O2|Chemical Name: N-[3-fluoro-5-(pyridin-3-yl)phenyl]-5-methoxy-6-(trifluoromethyl)-2,3-dihydro-1H-indole-1-carboxamide|Smiles: COC1=CC2CCN(C(=O)NC3=CC(F)=CC(=C3)C3C=NC=CC=3)C=2C=C1C(F)(F)F|InChiKey: RRJLJKRFFRZRAF-UHFFFAOYSA-N|InChi: InChI=1S/C22H17F4N3O2/c1-31-20-9-13-4-6-29(19(13)11-18(20)22(24,25)26)21(30)28-17-8-15(7-16(23)10-17)14-3-2-5-27-12-14/h2-3,5,7-12H,4,6H2,1H3,(H,28,30)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.PMID:35116795 |Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vivo:|SB228357 (0-10 mg/kg; oral administration; for 90 minutes; male Sprague Dawley rats) treatment significantly reverses Haloperidol-induced catalepsy.|Products are for research use only. Not for human use.|
