Product Name :
Rapanone
Description:
Rapanone is a natural benzoquinone. Rapanone exhibits a broad spectrum of biological actions, including anti-tumor, antioxidant, anti-inflammatory, antibacterial and antiparasitic. Rapanone also is a potent and selective human synovial PLA2 inhibitor, with an IC50 of 2.6 μM.
CAS:
573-40-0
Molecular Weight:
322.44
Formula:
C19H30O4
Chemical Name:
2,5-dihydroxy-3-tridecylcyclohexa-2,5-diene-1,4-dione
Smiles :
CCCCCCCCCCCCCC1C(=O)C(O)=CC(=O)C=1O
InChiKey:
AMKNOBHCKRZHIO-UHFFFAOYSA-N
InChi :
InChI=1S/C19H30O4/c1-2-3-4-5-6-7-8-9-10-11-12-13-15-18(22)16(20)14-17(21)19(15)23/h14,20,23H,2-13H2,1H3
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
Rapanone is a natural benzoquinone. Rapanone exhibits a broad spectrum of biological actions, including anti-tumor, antioxidant, anti-inflammatory, antibacterial and antiparasitic. Rapanone also is a potent and selective human synovial PLA2 inhibitor, with an IC50 of 2.6 μM.|Product information|CAS Number: 573-40-0|Molecular Weight: 322.44|Formula: C19H30O4|Chemical Name: 2,5-dihydroxy-3-tridecylcyclohexa-2,5-diene-1,4-dione|Smiles: CCCCCCCCCCCCCC1C(=O)C(O)=CC(=O)C=1O|InChiKey: AMKNOBHCKRZHIO-UHFFFAOYSA-N|InChi: InChI=1S/C19H30O4/c1-2-3-4-5-6-7-8-9-10-11-12-13-15-18(22)16(20)14-17(21)19(15)23/h14,20,23H,2-13H2,1H3|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Baclofen} MedChemExpress|{Baclofen} Membrane Transporter/Ion Channel|{Baclofen} Purity & Documentation|{Baclofen} In stock|{Baclofen} custom synthesis|{Baclofen} Cancer} |Shelf Life: ≥12 months if stored properly.{{5-Ethynyl-2′-deoxyuridine} MedChemExpress|{5-Ethynyl-2′-deoxyuridine} PROTAC Linkers|{5-Ethynyl-2′-deoxyuridine} NF-κB|{5-Ethynyl-2′-deoxyuridine} Technical Information|{5-Ethynyl-2′-deoxyuridine} In Vitro|{5-Ethynyl-2′-deoxyuridine} custom synthesis} |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.PMID:24456950 |Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|Rapanone (10-40 μM; 24 h) inhibits the cell viability, with IC50s of 35.58 μM and 27.89 μM for primary rats hepatocytes and HepG2 cells, respectively. Rapanone (10-40 μM; 24 h) induces a concentration-dependent mitochondrial membrane potential dissipation, ATP depletion, hydrogen peroxide generation and, phosphatidyl serine externalization in HepG2 cells. Rapanone inhibits electron transport at Complex III and promotes mitochondrial dysfunction.|In Vivo:|Rapanone (2.5-10 mg/kg; i.p.) exhibits anti-inflammatory effects in the carrageenan paw oedema model in mice.|Products are for research use only. Not for human use.|
