Product Name :
Perhexiline Maleate
Description:
Perhexiline is a carnitine palmitoyltransferase 1 (CPT1) and CPT2 inhibitor that was originally developed as an anti-anginal drug.
CAS:
6724-53-4
Molecular Weight:
393.56
Formula:
C23H39NO4
Chemical Name:
2-(2,2-dicyclohexylethyl)piperidine maleate
Smiles :
OC(=O)/C=C/C(O)=O.C(C(C1CCCCC1)C1CCCCC1)C1CCCCN1
InChiKey:
JDZOTSLZMQDFLG-WLHGVMLRSA-N
InChi :
InChI=1S/C19H35N.C4H4O4/c1-3-9-16(10-4-1)19(17-11-5-2-6-12-17)15-18-13-7-8-14-20-18;5-3(6)1-2-4(7)8/h16-20H,1-15H2;1-2H,(H,5,6)(H,7,8)/b;2-1+
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Sirukumab} medchemexpress|{Sirukumab} Immunology/Inflammation|{Sirukumab} Technical Information|{Sirukumab} References|{Sirukumab} custom synthesis|{Sirukumab} Epigenetics}
Shelf Life:
≥12 months if stored properly.{{Norepinephrine} web|{Norepinephrine} Adrenergic Receptor|{Norepinephrine} Protocol|{Norepinephrine} Purity|{Norepinephrine} custom synthesis|{Norepinephrine} Cancer}
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
Perhexiline is a carnitine palmitoyltransferase 1 (CPT1) and CPT2 inhibitor that was originally developed as an anti-anginal drug.PMID:35567400 |Product information|CAS Number: 6724-53-4|Molecular Weight: 393.56|Formula: C23H39NO4|Chemical Name: 2-(2,2-dicyclohexylethyl)piperidine maleate|Smiles: OC(=O)/C=C/C(O)=O.C(C(C1CCCCC1)C1CCCCC1)C1CCCCN1|InChiKey: JDZOTSLZMQDFLG-WLHGVMLRSA-N|InChi: InChI=1S/C19H35N.C4H4O4/c1-3-9-16(10-4-1)19(17-11-5-2-6-12-17)15-18-13-7-8-14-20-18;5-3(6)1-2-4(7)8/h16-20H,1-15H2;1-2H,(H,5,6)(H,7,8)/b;2-1+|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: Ethanol : 20 mg/mL (50.82 mM; Need ultrasonic) DMSO : 5 mg/mL (12.70 mM; Need ultrasonic)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|At 24, 48 and 72 h of treatment with 0.01 and 1 μM of Perhexiline , NDM29 ncRNA expression level in SH-SY5Y cells is progressively increased, reaching a peak after 48 hours of treatment. Perhexiline treatment increases the susceptibility of NB cells to antiblastic treatments. Co-administration of Perhexiline maleate potentiates the efficacy of cisplatin to reduce the in vitro clonogenic potential of NB cells.|In Vivo:|The co-administration of Perhexiline and cisplatin yields a clear enhancement of antitumor effects, resulting in a significantly improved progression-free survival as compared with mice treated with DMSO. Perhexiline favors NB cell transition to differentiated phenotype.|References:|Kennedy JA, et al. Inhibition of carnitine palmitoyltransferase-1 in rat heart and liver by Perhexiline and amiodarone. Biochem Pharmacol. 1996 Jul 26;52(2):273-80.Vella S, et al. Perhexiline maleate enhances antitumor efficacy of cisplatin in neuroblastoma by inducing over-expression of NDM29 ncRNA. Sci Rep. 2015 Dec 17;5:18144.Products are for research use only. Not for human use.|
