Product Name :
N-Desmethyl-Apalutamide
Description:
N-Desmethyl Apalutamide is an active metabolite of Apalutamide. N-Desmethyl Apalutamide is a less potent antagonist of the androgen receptor and is responsible for one-third of the activity of Apalutamide. The formation of N-Desmethyl Apalutamide mediated predominantly by CYP2C8 and CYP3A4. N-Desmethyl Apalutamide is moderate to strong CYP3A4 and CYP2B6 inducer and has an excellent plasma-proteins bound concentration.
CAS:
1332391-11-3
Molecular Weight:
463.41
Formula:
C20H13F4N5O2S
Chemical Name:
4-{7-[6-cyano-5-(trifluoromethyl)pyridin-3-yl]-8-oxo-6-sulfanylidene-5,7-diazaspiro[3.4]octan-5-yl}-2-fluorobenzamide
Smiles :
NC(=O)C1=CC=C(C=C1F)N1C(=S)N(C2C=C(C(C#N)=NC=2)C(F)(F)F)C(=O)C21CCC2
InChiKey:
BAANHOAPFBHUDX-UHFFFAOYSA-N
InChi :
InChI=1S/C20H13F4N5O2S/c21-14-7-10(2-3-12(14)16(26)30)29-18(32)28(17(31)19(29)4-1-5-19)11-6-13(20(22,23)24)15(8-25)27-9-11/h2-3,6-7,9H,1,4-5H2,(H2,26,30)
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
N-Desmethyl Apalutamide is an active metabolite of Apalutamide. N-Desmethyl Apalutamide is a less potent antagonist of the androgen receptor and is responsible for one-third of the activity of Apalutamide. The formation of N-Desmethyl Apalutamide mediated predominantly by CYP2C8 and CYP3A4. N-Desmethyl Apalutamide is moderate to strong CYP3A4 and CYP2B6 inducer and has an excellent plasma-proteins bound concentration.{{KH-3} medchemexpress|{KH-3} HuR|{KH-3} Biological Activity|{KH-3} In Vivo|{KH-3} manufacturer|{KH-3} Autophagy} |Product information|CAS Number: 1332391-11-3|Molecular Weight: 463.{{Tideglusib} medchemexpress|{Tideglusib} Stem Cell/Wnt|{Tideglusib} Biological Activity|{Tideglusib} Data Sheet|{Tideglusib} manufacturer|{Tideglusib} Cancer} 41|Formula: C20H13F4N5O2S|Chemical Name: 4-{7-[6-cyano-5-(trifluoromethyl)pyridin-3-yl]-8-oxo-6-sulfanylidene-5,7-diazaspiro[3.PMID:23509865 4]octan-5-yl}-2-fluorobenzamide|Smiles: NC(=O)C1=CC=C(C=C1F)N1C(=S)N(C2C=C(C(C#N)=NC=2)C(F)(F)F)C(=O)C21CCC2|InChiKey: BAANHOAPFBHUDX-UHFFFAOYSA-N|InChi: InChI=1S/C20H13F4N5O2S/c21-14-7-10(2-3-12(14)16(26)30)29-18(32)28(17(31)19(29)4-1-5-19)11-6-13(20(22,23)24)15(8-25)27-9-11/h2-3,6-7,9H,1,4-5H2,(H2,26,30)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|
