Product Name :
KCC2 blocker 1
Description:
KCC2 blocker 1 is an orally active and selective K+-Cl- cotransporter KCC2 blocker with an IC50 of 1 μM. KCC2 blocker 1 is a benzyl prolinate and has antiepileptic effect.
CAS:
1228439-36-8
Molecular Weight:
415.50
Formula:
C22H25NO5S
Chemical Name:
benzyl 1-acetyl-2-[(4-methanesulfonylphenyl)methyl]pyrrolidine-2-carboxylate
Smiles :
CC(=O)N1CCCC1(CC1C=CC(=CC=1)S(C)(=O)=O)C(=O)OCC1C=CC=CC=1
InChiKey:
XFXZWVGQXNFWDE-UHFFFAOYSA-N
InChi :
InChI=1S/C22H25NO5S/c1-17(24)23-14-6-13-22(23,21(25)28-16-19-7-4-3-5-8-19)15-18-9-11-20(12-10-18)29(2,26)27/h3-5,7-12H,6,13-16H2,1-2H3
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
KCC2 blocker 1 is an orally active and selective K+-Cl- cotransporter KCC2 blocker with an IC50 of 1 μM. KCC2 blocker 1 is a benzyl prolinate and has antiepileptic effect.|Product information|CAS Number: 1228439-36-8|Molecular Weight: 415.50|Formula: C22H25NO5S|Chemical Name: benzyl 1-acetyl-2-[(4-methanesulfonylphenyl)methyl]pyrrolidine-2-carboxylate|Smiles: CC(=O)N1CCCC1(CC1C=CC(=CC=1)S(C)(=O)=O)C(=O)OCC1C=CC=CC=1|InChiKey: XFXZWVGQXNFWDE-UHFFFAOYSA-N|InChi: InChI=1S/C22H25NO5S/c1-17(24)23-14-6-13-22(23,21(25)28-16-19-7-4-3-5-8-19)15-18-9-11-20(12-10-18)29(2,26)27/h3-5,7-12H,6,13-16H2,1-2H3|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : 250 mg/mL (601.{{Velpatasvir} medchemexpress|{Velpatasvir} Anti-infection|{Velpatasvir} Purity & Documentation|{Velpatasvir} In stock|{Velpatasvir} manufacturer|{Velpatasvir} Epigenetics} 68 mM; Need ultrasonic).{{Pseudouridine} site|{Pseudouridine} Metabolic Enzyme/Protease|{Pseudouridine} Purity & Documentation|{Pseudouridine} References|{Pseudouridine} supplier|{Pseudouridine} Autophagy} |Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.PMID:24367939 |Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|KCC2 blocker 1 (compound 13; 100 μM) inhibits NKCC1 with 35%.|In Vivo:|KCC2 blocker 1 (compound 13; 1 mg/kg iv and 6 mg/kg po) has a t1/2 of 0.3 hours, a CL of 26 mL/min/kg, a C max of 457 ng/mL and a AUC of 726 ng•h/mL for male Wistar rats.|Products are for research use only. Not for human use.|
