Product Name :
CCR2 antagonist 4
Description:
CCR2 antagonist 4 (Teijin compound 1) is a potent and specific CCR2 antagonist, with IC50s of 180 nM for CCR2b. CCR2 antagonist 4 potently inhibits MCP-1-induced chemotaxis with an IC50 of 24 nM.
CAS:
226226-39-7
Molecular Weight:
439.86
Formula:
C21H21ClF3N3O2
Chemical Name:
N-[(3R)-1-[(4-chlorophenyl)methyl]pyrrolidin-3-yl]-2-{[3-(trifluoromethyl)phenyl]formamido}acetamide
Smiles :
O=C(CNC(=O)C1=CC(=CC=C1)C(F)(F)F)N[C@H]1CN(CC2C=CC(Cl)=CC=2)CC1
InChiKey:
BAOQJSULMWXFRK-GOSISDBHSA-N
InChi :
InChI=1S/C21H21ClF3N3O2/c22-17-6-4-14(5-7-17)12-28-9-8-18(13-28)27-19(29)11-26-20(30)15-2-1-3-16(10-15)21(23,24)25/h1-7,10,18H,8-9,11-13H2,(H,26,30)(H,27,29)/t18-/m1/s1
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Cobicistat} web|{Cobicistat} Anti-infection|{Cobicistat} Protocol|{Cobicistat} References|{Cobicistat} custom synthesis|{Cobicistat} Autophagy}
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
CCR2 antagonist 4 (Teijin compound 1) is a potent and specific CCR2 antagonist, with IC50s of 180 nM for CCR2b. CCR2 antagonist 4 potently inhibits MCP-1-induced chemotaxis with an IC50 of 24 nM.|Product information|CAS Number: 226226-39-7|Molecular Weight: 439.86|Formula: C21H21ClF3N3O2|Chemical Name: N-[(3R)-1-[(4-chlorophenyl)methyl]pyrrolidin-3-yl]-2-{[3-(trifluoromethyl)phenyl]formamido}acetamide|Smiles: O=C(CNC(=O)C1=CC(=CC=C1)C(F)(F)F)N[C@H]1CN(CC2C=CC(Cl)=CC=2)CC1|InChiKey: BAOQJSULMWXFRK-GOSISDBHSA-N|InChi: InChI=1S/C21H21ClF3N3O2/c22-17-6-4-14(5-7-17)12-28-9-8-18(13-28)27-19(29)11-26-20(30)15-2-1-3-16(10-15)21(23,24)25/h1-7,10,18H,8-9,11-13H2,(H,26,30)(H,27,29)/t18-/m1/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : ≥ 50 mg/mL (113.{{Apolipoprotein A-I Protein, Human} web|{Apolipoprotein A-I Protein, Human} Biological Activity|{Apolipoprotein A-I Protein, Human} Data Sheet|{Apolipoprotein A-I Protein, Human} supplier|{Apolipoprotein A-I Protein, Human} Cancer} 67 mM).PMID:24578169 |Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|Ile263 and Thr292 in CCR2 contribute significantly to binding of Teijin compound 1 in CCR2. Residue Glu291 in TM7, a highly conserved residue in many CC chemokine receptors, contributes substantially to binding of the protonated CCR2 antagonist 4, and CCL2. His121 on TM3 and Ile263 on TM6 also strongly interact with CCR2 antagonist 4. In ApoE-deficient mice, Vp-TSL targets specifically aortic plaque endothelial VCAM-1 and CCR2 antagonist 4 reduces the mouse monocyte/macrophage cell line (RAW 264.7) adhesion/ infiltration into the aorta.|Products are for research use only. Not for human use.|
