Product Name :
MLN 2480
Description:
TAK-580, also known as MLN2480, BIIB024, and AMG 2112819, is an oral, selective pan-Raf kinase inhibitor. The Raf kinases (A-Raf, B-Raf and C-Raf) are key regulators of cell proliferation and survival within the mitogen-activated protein kinase (MAPK) pathway. The MAPK pathway is frequently disregulated in human cancers, often via activating mutations of Ras or Raf.
CAS:
1096708-71-2
Molecular Weight:
506.29
Formula:
C17H12Cl2F3N7O2S
Chemical Name:
6-amino-5-chloro-N-[(1R)-1-(5-{[5-chloro-4-(trifluoromethyl)pyridin-2-yl]carbamoyl}-1,3-thiazol-2-yl)ethyl]pyrimidine-4-carboxamide
Smiles :
C[C@@H](NC(=O)C1=NC=NC(N)=C1Cl)C1=NC=C(S1)C(=O)NC1=CC(=C(Cl)C=N1)C(F)(F)F
InChiKey:
VWMJHAFYPMOMGF-ZCFIWIBFSA-N
InChi :
InChI=1S/C17H12Cl2F3N7O2S/c1-6(28-15(31)12-11(19)13(23)27-5-26-12)16-25-4-9(32-16)14(30)29-10-2-7(17(20,21)22)8(18)3-24-10/h2-6H,1H3,(H,28,31)(H2,23,26,27)(H,24,29,30)/t6-/m1/s1
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥360 days if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
TAK-580, also known as MLN2480, BIIB024, and AMG 2112819, is an oral, selective pan-Raf kinase inhibitor. The Raf kinases (A-Raf, B-Raf and C-Raf) are key regulators of cell proliferation and survival within the mitogen-activated protein kinase (MAPK) pathway. The MAPK pathway is frequently disregulated in human cancers, often via activating mutations of Ras or Raf.|Product information|CAS Number: 1096708-71-2|Molecular Weight: 506.29|Formula: C17H12Cl2F3N7O2S|Chemical Name: 6-amino-5-chloro-N-[(1R)-1-(5-{[5-chloro-4-(trifluoromethyl)pyridin-2-yl]carbamoyl}-1,3-thiazol-2-yl)ethyl]pyrimidine-4-carboxamide|Smiles: C[C@@H](NC(=O)C1=NC=NC(N)=C1Cl)C1=NC=C(S1)C(=O)NC1=CC(=C(Cl)C=N1)C(F)(F)F|InChiKey: VWMJHAFYPMOMGF-ZCFIWIBFSA-N|InChi: InChI=1S/C17H12Cl2F3N7O2S/c1-6(28-15(31)12-11(19)13(23)27-5-26-12)16-25-4-9(32-16)14(30)29-10-2-7(17(20,21)22)8(18)3-24-10/h2-6H,1H3,(H,28,31)(H2,23,26,27)(H,24,29,30)/t6-/m1/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Xylan} web|{Xylan} Metabolic Enzyme/Protease|{Xylan} Technical Information|{Xylan} In Vivo|{Xylan} custom synthesis|{Xylan} Autophagy} |Shelf Life: ≥360 days if stored properly.{{Rivaroxaban} site|{Rivaroxaban} Factor Xa|{Rivaroxaban} Protocol|{Rivaroxaban} Purity|{Rivaroxaban} custom synthesis|{Rivaroxaban} Epigenetic Reader Domain} |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.PMID:23710097 |Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|
