Product Name :
ADH-6
Description:
ADH-6 is a tripyridylamide compound. ADH-6 abrogates self-assembly of the aggregation-nucleating subdomain of mutant p53 DBD. ADH-6 targets and dissociates mutant p53 aggregates in human cancer cells, which restores p53’s transcriptional activity, leading to cell cycle arrest and apoptosis. ADH-6 has the potential for the research of cancer diseases.
CAS:
2227429-65-2
Molecular Weight:
640.64
Formula:
C29H36N8O9
Chemical Name:
Smiles :
COC(=O)C1=CC=C(NC(=O)C2=CC=C(NC(=O)C3=CC=C(C(=N3)OCCCC)[N+]([O-])=O)C(=N2)OCCCN)C(=N1)OCCCN
InChiKey:
KDVRSKDEDDWURT-UHFFFAOYSA-N
InChi :
InChI=1S/C29H36N8O9/c1-3-4-15-46-28-23(37(41)42)12-11-19(35-28)25(39)32-20-8-7-18(34-26(20)44-16-5-13-30)24(38)33-21-9-10-22(29(40)43-2)36-27(21)45-17-6-14-31/h7-12H,3-6,13-17,30-31H2,1-2H3,(H,32,39)(H,33,38)
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
ADH-6 is a tripyridylamide compound. ADH-6 abrogates self-assembly of the aggregation-nucleating subdomain of mutant p53 DBD. ADH-6 targets and dissociates mutant p53 aggregates in human cancer cells, which restores p53’s transcriptional activity, leading to cell cycle arrest and apoptosis. ADH-6 has the potential for the research of cancer diseases.|Product information|CAS Number: 2227429-65-2|Molecular Weight: 640.64|Formula: C29H36N8O9|Smiles: COC(=O)C1=CC=C(NC(=O)C2=CC=C(NC(=O)C3=CC=C(C(=N3)OCCCC)[N+]([O-])=O)C(=N2)OCCCN)C(=N1)OCCCN|InChiKey: KDVRSKDEDDWURT-UHFFFAOYSA-N|InChi: InChI=1S/C29H36N8O9/c1-3-4-15-46-28-23(37(41)42)12-11-19(35-28)25(39)32-20-8-7-18(34-26(20)44-16-5-13-30)24(38)33-21-9-10-22(29(40)43-2)36-27(21)45-17-6-14-31/h7-12H,3-6,13-17,30-31H2,1-2H3,(H,32,39)(H,33,38)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: To be determined|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Amitriptyline} site|{Amitriptyline} 5-HT Receptor|{Amitriptyline} Biological Activity|{Amitriptyline} Formula|{Amitriptyline} supplier|{Amitriptyline} Autophagy} |Shelf Life: ≥12 months if stored properly.{{Encorafenib} web|{Encorafenib} MAPK/ERK Pathway|{Encorafenib} Technical Information|{Encorafenib} Formula|{Encorafenib} supplier|{Encorafenib} Autophagy} |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.PMID:23833812 |Drug Formulation: To be determined|HS Tariff Code: 382200|References:|Palanikumar L, et al. Protein mimetic amyloid inhibitor potently abrogates cancer-associated mutant p53 aggregation and restores tumor suppressor function. Nat Commun. 2021;12(1):3962.Products are for research use only. Not for human use.|
