Product Name :
NSC 3852
Description:
NSC 3852 is a potent inhibitor of histone deacetylase . Histone deacetylases (HADC) are a series of enzymes that remove acetyl groups from an ε-N-acetyl lysine amino acid on a histone and make the histones to wrap the DNA more tightly, which prevent transcription. In MCF-7 human breast cancer cells, NSC 3852 induced the formation of the DMPO-OH adduct, which was catalyzed by superoxide dismutase. The result suggested that NSC 3852 induced generation of superoxide and reactive oxygen species (ROS), which produced DNA damage and induced apoptosis. Also, NSC 3852 resulted in cells accumulation in G0, hypophosphorylated retinoblastoma protein(Rb) and reduced E2F1 and Myc protein . In HS68 cell, NSC 3852 inhibited Toxoplasma gondii tachyzoite propagation with EC50 value of 78.6 nM. Also, in human red blood cells, NSC 3852 inhibited Plasmodium falciparum growth with EC50 value of 1.3 μM. NSC 3852 inhibited Toxoplasma gondii tachyzoite propagation by involving redox reactions .
CAS:
3565-26-2
Molecular Weight:
174.16
Formula:
C9H6N2O2
Chemical Name:
5-nitrosoquinolin-8-ol
Smiles :
OC1C=CC(N=O)=C2C=CC=NC2=1
InChiKey:
RZWRYPGAUIOOMK-UHFFFAOYSA-N
InChi :
InChI=1S/C9H6N2O2/c12-8-4-3-7(11-13)6-2-1-5-10-9(6)8/h1-5,12H
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Selenomethionine} site|{Selenomethionine} Autophagy|{Selenomethionine} Technical Information|{Selenomethionine} Formula|{Selenomethionine} custom synthesis|{Selenomethionine} Autophagy}
Shelf Life:
≥12 months if stored properly.{{Dehydroepiandrosterone} MedChemExpress|{Dehydroepiandrosterone} Metabolic Enzyme/Protease|{Dehydroepiandrosterone} Technical Information|{Dehydroepiandrosterone} Formula|{Dehydroepiandrosterone} manufacturer|{Dehydroepiandrosterone} Autophagy}
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.PMID:35345980
Additional information:
NSC 3852 is a potent inhibitor of histone deacetylase . Histone deacetylases (HADC) are a series of enzymes that remove acetyl groups from an ε-N-acetyl lysine amino acid on a histone and make the histones to wrap the DNA more tightly, which prevent transcription. In MCF-7 human breast cancer cells, NSC 3852 induced the formation of the DMPO-OH adduct, which was catalyzed by superoxide dismutase. The result suggested that NSC 3852 induced generation of superoxide and reactive oxygen species (ROS), which produced DNA damage and induced apoptosis. Also, NSC 3852 resulted in cells accumulation in G0, hypophosphorylated retinoblastoma protein(Rb) and reduced E2F1 and Myc protein . In HS68 cell, NSC 3852 inhibited Toxoplasma gondii tachyzoite propagation with EC50 value of 78.6 nM. Also, in human red blood cells, NSC 3852 inhibited Plasmodium falciparum growth with EC50 value of 1.3 μM. NSC 3852 inhibited Toxoplasma gondii tachyzoite propagation by involving redox reactions .|Product information|CAS Number: 3565-26-2|Molecular Weight: 174.16|Formula: C9H6N2O2|Chemical Name: 5-nitrosoquinolin-8-ol|Smiles: OC1C=CC(N=O)=C2C=CC=NC2=1|InChiKey: RZWRYPGAUIOOMK-UHFFFAOYSA-N|InChi: InChI=1S/C9H6N2O2/c12-8-4-3-7(11-13)6-2-1-5-10-9(6)8/h1-5,12H|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|
