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healthcareReviewAdult Granulosa Cell Tumor in Pregnancy: A new Case and also a Critique of the LiteratureSofia Guidi 1, , Vincenzo Berghella two , Giovanni Scambia 1 , Anna Fagotti 1 , Annalisa Vidiri 1 , Stefano Restaino 3 , Giuseppe Vizzielli 1,three , Frediano Inzani four and Anna Franca CavaliereDepartment of Obstetrics and Gynecology, Fondazione Policlinico Universitario Agostino Gemelli, IRCCS, 00168 Rome, Italy; [email protected] (G.S.); [email protected] (A.F.); [email protected] (A.V.); [email protected] (G.V.) Division of Maternal-Fetal Medicine, Division of Obstetrics and Gynecology, Sidney Kimmel Health-related College, Thomas Jefferson University, Philadelphia, PA 19107, USA; [email protected] Department of Obstetrics, Gyneacology and Pediatrics, Udine University Hospital, DAME, 33100 Udine, Italy; [email protected] Gynecopathology and Breast Pathology Unit, Department of Woman’s Well being Science, Fondazione Policlinico Universitario Agostino Gemelli, IRCCS, 00168 Rome, Italy; [email protected] Azienda USL Toscana Centro, Gynecology and Obstetrics Department, Santo Stefano Hospital, 59100 Prato, Italy; [email protected] Correspondence: [email protected]; Tel.: +39-33-3446-Citation: Guidi, S.; Berghella, V.; Scambia, G.; Fagotti, A.; Vidiri, A.; Restaino, S.; Vizzielli, G.; Inzani, F.; Cavaliere, A.F. Adult Granulosa Cell Tumor in Pregnancy: A new Case along with a Assessment on the Literature. FAUC 365 Technical Information Healthcare 2021, 9, 1455. https:// doi.org/10.3390/healthcare9111455 Academic Editor: Edward J. Pavlik Received: 24 August 2021 Accepted: 23 October 2021 Published: 27 OctoberAbstract: Granulosa cell tumors are uncommon ovarian tumors that could arise during pregnancy. We present a new case of recurrent adult granulosa cell tumor (AGCT) in pregnancy and a systematic critique on the literature. The new case described can be a 41-year-old lady G5P1122 having a prior history of AGCT that was referred to our center at 29 weeks due to a symptomatic abdominal mass, compatible using a doable recurrence of AGCT. At 36 + 3 weeks, she Ziritaxestat supplier underwent a cesarean delivery for preterm labor and also a total hysterectomy with a radical surgical staging. A healthy female infant was delivered. The patient received a platinum-based chemotherapy, using a 26-month follow-up adverse for recurrence. Analyzing our case with the 4 identified by the literature review, 3 were recurrent and two had been key AGCT. Only 1 essential surgery for AGCT at 15 weeks, even though a further underwent chemotherapy in pregnancy. Within the other three circumstances, surgery for AGCT was performed at the time of cesarean delivery. There have been three circumstances of preterm delivery. All 5 pregnancies resulted inside the birth of reside babies with weight adequate for gestational age. In conclusion, AGCT diagnosed in pregnancy is uncommon, reported in only 5 cases. All gave birth to live babies inside the third trimester, and maternal outcome at as much as 18 months showed no recurrence. Key phrases: granulosa cell tumor; pregnancy; recurrence; ovari.
