Pective evaluation of individuals with diagnosis of gallbladder cancer between ,inside a referral tertiary center. Outcomes: We incorporated individuals ( females),with a median age of years. The median time of followup was months,having a mortality price of (n. The majority of sufferers PubMed ID:https://www.ncbi.nlm.nih.gov/pubmed/21046372 ( had history of cholelithiasis and were diagnosed soon after cholecystectomy ( of those within the context of acute cholecystitis). Probably the most popular symptoms reported at admission were abdominal pain (jaundice (and nauseavomiting The majority with the individuals had slight cholestasis in laboratorial evaluation. The neoplasms involved the gallbladder body or had been panvesicular in of cases. A nonspecific adenocarcinoma was essentially the most prevalent diagnosis (using a median size of mm. At diagnosis, were in an sophisticated stage (IIIIV). A surgery of curative intent was performed in of individuals. The palliative approaches additional frequently used were percutaneous drainage ( and chemorradiotherapy An endoscopic drainage was performed only in patients The mortality price at ,,and months was ,, and ,respectively. The presence of cholestasis (p.) and renal dysfunction (p.) at diagnosis correlated independently with early mortality. Conclusion: The gallbladder carcinoma was extra prevalent in ladies with advanced age,in numerous circumstances with prior cholelithiasis and in an sophisticated stage at diagnosis. Adenocarcinoma was the most typical histological form. Despite the high price of surgical approaches for curative intent, did not survive beyond years just after the diagnosis. Disclosure of Interest: None declaredUnited European Gastroenterology Journal (S) Abstract number P Table . Hepatogastrostomy jejunostomy[HG(J)S] Number of the pts (AB) MaleFemale Mean age (range) years Malignities Benign pathologies Indications (AB) Technical accomplishment price AB (Variety of the individuals)# Critical Complications:AB [ . ] (Bleeding in two casesone died,a single surgery; cholangitis and sepsis in one particular case; perforation in two cases (surgery needed) Choledocho or cystoduodenostomy [CD(Cy)S] [ ] (Bile leak and biloma formation ( cm) requiring surgery in onecardiopulmonary arrest and death in one particular) CholecystoCholedochalRendezvous gastrostomy(CRV) jejunostomy[CG(J)S] Total [ ] (Surgery as a result of guidewire knotting in duodenum) [ A[ . ]] ( death,surgery,extended intensive care keep)P DIRECT RETROGRADE CHOLANGIOSCOPYDIRECTED BIOPSY IS SUPERIOR TO FLUOROSCOPYGUIDED BIOPSY TO DIFFERENTIATE INDETERMINATE BILIARY STRICTURE Within the DISTAL Typical BILE DUCT,BUT NOT Inside the PORTA HEPATIS D. Walter,M. FriedrichRust,S. Zeuzem,J. Albert Health-related Department ,University ML281 site hospital Frankfurt,Frankfurt,Germany Speak to Email Address: dirk.walterkgu.de Introduction: Differentiation of indeterminate biliary stricture (IBS) by imaging modalities is limited. Definite diagnosis is based on histopathology,but higher rates of false damaging biopsies constrain the clinical management. Aims Approaches Aims: To investigate reason of high false damaging results of intraductal biopsies obtained below fluoroscopic guidance in comparison to direct retrograde cholangioscopy (DRC). Methods: All individuals have been retrospectively integrated who presented for diagnostic workup of IBS at our University hospital and who underwent an intraductal biopsy involving and . Histopathological results of fluoroscopic vs DRCdirected intraductal biopsies have been compared using the golden standard of either postoperative histology or followup of at the very least one year and underlying disease of false unfavorable biopsies.