E. A part of his explanation for the error was his willingness to capitulate when tired: `I didn’t ask for any medical history or something like that . . . more than the phone at three or 4 o’clock [in the morning] you simply say yes to anything’ pnas.1602641113 Interviewee 25. In spite of sharing these comparable characteristics, there were some differences in error-producing PNPP biological activity conditions. With KBMs, doctors were aware of their expertise deficit at the time of the prescribing choice, unlike with RBMs, which led them to take one of two pathways: approach other individuals for314 / 78:2 / Br J Clin PharmacolLatent conditionsSteep hierarchical structures inside health-related teams prevented physicians from seeking support or indeed receiving adequate support, highlighting the importance from the prevailing medical culture. This varied between specialities and accessing suggestions from seniors appeared to become extra problematic for FY1 trainees operating in Velpatasvir price surgical specialities. Interviewee 22, who worked on a surgical ward, described how, when he approached seniors for assistance to stop a KBM, he felt he was annoying them: `Q: What created you believe which you might be annoying them? A: Er, just because they’d say, you know, very first words’d be like, “Hi. Yeah, what’s it?” you understand, “I’ve scrubbed.” That’ll be like, kind of, the introduction, it would not be, you understand, “Any challenges?” or anything like that . . . it just doesn’t sound really approachable or friendly around the telephone, you know. They just sound rather direct and, and that they had been busy, I was inconveniencing them . . .’ Interviewee 22. Medical culture also influenced doctor’s behaviours as they acted in approaches that they felt have been needed so as to fit in. When exploring doctors’ reasons for their KBMs they discussed how they had chosen to not seek suggestions or data for worry of seeking incompetent, particularly when new to a ward. Interviewee 2 beneath explained why he did not check the dose of an antibiotic despite his uncertainty: `I knew I should’ve looked it up cos I didn’t genuinely know it, but I, I feel I just convinced myself I knew it becauseExploring junior doctors’ prescribing mistakesI felt it was one thing that I should’ve identified . . . because it is very uncomplicated to acquire caught up in, in becoming, you understand, “Oh I am a Physician now, I know stuff,” and together with the stress of men and women who’re perhaps, sort of, somewhat bit more senior than you thinking “what’s incorrect with him?” ‘ Interviewee 2. This behaviour was described as subsiding with time, suggesting that it was their perception of culture that was the latent situation instead of the actual culture. This interviewee discussed how he ultimately discovered that it was acceptable to verify data when prescribing: `. . . I locate it rather good when Consultants open the BNF up in the ward rounds. And also you think, well I’m not supposed to know each and every single medication there is certainly, or the dose’ Interviewee 16. Medical culture also played a role in RBMs, resulting from deference to seniority and unquestioningly following the (incorrect) orders of senior doctors or knowledgeable nursing staff. A very good example of this was offered by a doctor who felt relieved when a senior colleague came to help, but then prescribed an antibiotic to which the patient was allergic, despite having currently noted the allergy: `. journal.pone.0169185 . . the Registrar came, reviewed him and mentioned, “No, no we should really give Tazocin, penicillin.” And, erm, by that stage I’d forgotten that he was penicillin allergic and I just wrote it around the chart without the need of considering. I say wi.E. A part of his explanation for the error was his willingness to capitulate when tired: `I did not ask for any healthcare history or something like that . . . over the phone at 3 or 4 o’clock [in the morning] you simply say yes to anything’ pnas.1602641113 Interviewee 25. Despite sharing these similar qualities, there have been some differences in error-producing situations. With KBMs, medical doctors have been conscious of their understanding deficit in the time on the prescribing choice, in contrast to with RBMs, which led them to take one of two pathways: approach other people for314 / 78:two / Br J Clin PharmacolLatent conditionsSteep hierarchical structures within medical teams prevented physicians from searching for support or indeed getting adequate help, highlighting the value in the prevailing healthcare culture. This varied involving specialities and accessing suggestions from seniors appeared to be additional problematic for FY1 trainees functioning in surgical specialities. Interviewee 22, who worked on a surgical ward, described how, when he approached seniors for guidance to stop a KBM, he felt he was annoying them: `Q: What made you think which you could be annoying them? A: Er, just because they’d say, you realize, initially words’d be like, “Hi. Yeah, what’s it?” you know, “I’ve scrubbed.” That’ll be like, sort of, the introduction, it would not be, you realize, “Any troubles?” or anything like that . . . it just does not sound quite approachable or friendly around the telephone, you understand. They just sound rather direct and, and that they have been busy, I was inconveniencing them . . .’ Interviewee 22. Health-related culture also influenced doctor’s behaviours as they acted in ways that they felt had been important so that you can match in. When exploring doctors’ reasons for their KBMs they discussed how they had selected not to seek assistance or information for worry of hunting incompetent, especially when new to a ward. Interviewee 2 below explained why he did not verify the dose of an antibiotic regardless of his uncertainty: `I knew I should’ve looked it up cos I did not seriously know it, but I, I believe I just convinced myself I knew it becauseExploring junior doctors’ prescribing mistakesI felt it was one thing that I should’ve identified . . . since it is extremely straightforward to have caught up in, in becoming, you realize, “Oh I’m a Medical professional now, I know stuff,” and with all the pressure of people that are perhaps, kind of, slightly bit far more senior than you pondering “what’s wrong with him?” ‘ Interviewee two. This behaviour was described as subsiding with time, suggesting that it was their perception of culture that was the latent situation as opposed to the actual culture. This interviewee discussed how he ultimately discovered that it was acceptable to check details when prescribing: `. . . I obtain it fairly good when Consultants open the BNF up within the ward rounds. And also you assume, effectively I am not supposed to understand just about every single medication there is certainly, or the dose’ Interviewee 16. Medical culture also played a part in RBMs, resulting from deference to seniority and unquestioningly following the (incorrect) orders of senior doctors or skilled nursing staff. An excellent instance of this was provided by a doctor who felt relieved when a senior colleague came to help, but then prescribed an antibiotic to which the patient was allergic, regardless of obtaining already noted the allergy: `. journal.pone.0169185 . . the Registrar came, reviewed him and said, “No, no we must give Tazocin, penicillin.” And, erm, by that stage I’d forgotten that he was penicillin allergic and I just wrote it around the chart without considering. I say wi.