Y Genbank ID Respiration Pyrimidine metabolism Amino acid synthesis fig_4440944.three.peg.10065 259506366 fig_4440823.three.peg.83433 258543886 fig_4440944.three.peg.10065 160942077 fig_4440823.three.peg.212847 255323153 fig_4440943.three.peg.37808 fig_4440824.3.peg.113687 fig_4440452.7.peg.65716 fig_4440824.three.peg.204352 fig_4440824.three.peg.204352 fig_4440825.three.peg.10215 225570901 fig_4440824.3.peg.204352 fig_4440824.three.peg.4961 229828779 fig_4440613.three.peg.149199 fig_4440461.five.peg.1268 154495787 fig_4440946.3.peg.10812 fig_4440944.three.peg.10065 258543886 
Phosphoribosyl glycinamide synthetase phosphoribosylamine-glycine ligasePurine metabolism Pyruvate-Formate Lyase Beta-N-acetyl-D-hexosaminide N-acetylhexosaminohydrolase Respiration Glycosaminoglycan degradation Pyrimidine metabolism Amino acid transport and metabolism Complicated Carbohydrates Nitrogen Metabolism Amino acid synthesis Amino acid synthesis Amino acid synthesis Organic Acids Complicated Carbohydrates Amino acid synthesis Nitrogen Metabolism Pyrimidine metabolism Amino acid synthesis Amino acid synthesis Pyrimidine metabolism Glycan structures – degradation;Exotic Metabolisms Respiration three Cytosine deaminase Branched-chain-amino-acid transaminase Mannanase 4 Agamintase 3-isopropylmalate dehydrogenase Diaminopimelate epimerase 5 Diaminopimelate epimerase Methylmalonyl-CaA decarboxylase Alpha-Glucosidase 6 Diaminopimelate epimerase Agamintase Cytosine deaminase 7 Dihydrodipicolinate synthase Cystathionine gamma-synthase Uridine phosphorylase 8 Beta-D-glucuronidase Pyruvate-Formate Lyase Phosphoribosyl glycinamide synthetase phosphoribosylamine-glycine ligasePurine metabolism Caries-active 1 3-demethylubiquinone-9 3-methyltransferase Prephenate dehydrogenase Cysteine synthase A 2 Pyruvate-Formate Lyase N-acetylmuramoyl-L-alanine amidase Beta-D-glucuronidase 3 Geranyltranstransferase Cytosine deaminase Diaminopimelate epimerase 4 Carbon Monoxide Dehydrogenase Prephenate dehydrogenase Beta-ketoacyl-acyl-carrier-protein synthase III 5 Prephenate dehydrogenase Cysteine synthase A Cysteine synthase A six Branched-chain-amino-acid transaminase 
Pyruvate-Formate Lyase Adenylosuccinate synthetase 7 Dihydrodipicolinate synthase Prephenate dehydrogenase Arginosuccinate synthase 8 N-acetylmuramoyl-L-alanine amidase Quinolinate Synthase Cofactor Biosynthesis Amino acid synthesis Amino acid synthesis Respiration Glycan Biosynthesis and Metabolism Glycan structures – degradation;Exotic Metabolisms Isoprenoid biosynthesis Pyrimidine metabolism Amino acid synthesis Central Carbon Metabolism Pathways Amino acid synthesis Fatty Acid Biosynthesis Amino 16402044 acid synthesis Amino acid synthesis Amino acid synthesis Amino acid transport and metabolism Respiration Purine metabolism Amino acid synthesis Amino acid synthesis Amino acid synthesis Glycan Biosynthesis and Metabolism Cofactor Biosynthesis 241759137 fig_4440943.3.peg.33989 241760414 fig_4440944.3.peg.10065 218128624 218258198 237749332 229828779 fig_4440824.3.peg.204352 167748998 fig_4440943.3.peg.33989 227895174 fig_4440943.3.peg.33989 241760414 209907778 fig_4440610.three.peg.10420 fig_4440944.3.peg.10065 fig_4440949.three.peg.18491 229496628 fig_4440943.three.peg.33989 fig_4440939.3.peg.8046 218128624 227547856 9 Functional Gene Signature of Saliva Microbiota Gene name Pyruvate-Formate Lyase 9 Pyridoxal Kinase Serine hydroxymethyltransferase Prephenate dehydrogenase Every biomarker is often a triplet-feature set of microbial genes. doi:10.1371/journal.pone.0076458.t002 Gene category Respiration.Y Genbank ID Respiration Pyrimidine metabolism Amino acid synthesis fig_4440944.3.peg.10065 259506366 fig_4440823.three.peg.83433 258543886 fig_4440944.3.peg.10065 160942077 fig_4440823.3.peg.212847 255323153 fig_4440943.3.peg.37808 fig_4440824.three.peg.113687 fig_4440452.7.peg.65716 fig_4440824.three.peg.204352 fig_4440824.3.peg.204352 fig_4440825.3.peg.10215 225570901 fig_4440824.three.peg.204352 fig_4440824.three.peg.4961 229828779 fig_4440613.three.peg.149199 fig_4440461.five.peg.1268 154495787 fig_4440946.3.peg.10812 fig_4440944.three.peg.10065 258543886 Phosphoribosyl glycinamide synthetase phosphoribosylamine-glycine ligasePurine metabolism Pyruvate-Formate Lyase Beta-N-acetyl-D-hexosaminide N-acetylhexosaminohydrolase Respiration Glycosaminoglycan degradation Pyrimidine metabolism Amino acid transport and metabolism Complicated Carbohydrates Nitrogen Metabolism Amino acid synthesis Amino acid synthesis Amino acid synthesis Organic Acids Complicated Carbohydrates Amino acid synthesis Nitrogen Metabolism Pyrimidine metabolism Amino acid synthesis Amino acid synthesis Pyrimidine metabolism Glycan structures – degradation;Exotic Metabolisms Respiration three Cytosine deaminase Branched-chain-amino-acid transaminase Mannanase 4 Agamintase 3-isopropylmalate dehydrogenase Diaminopimelate epimerase 5 Diaminopimelate epimerase Methylmalonyl-CaA decarboxylase Alpha-Glucosidase six Diaminopimelate epimerase Agamintase Cytosine deaminase 7 Dihydrodipicolinate synthase Cystathionine gamma-synthase Uridine phosphorylase eight Beta-D-glucuronidase Pyruvate-Formate Lyase Phosphoribosyl glycinamide synthetase phosphoribosylamine-glycine ligasePurine metabolism Caries-active 1 3-demethylubiquinone-9 3-methyltransferase Prephenate dehydrogenase Cysteine synthase A two Pyruvate-Formate Lyase N-acetylmuramoyl-L-alanine amidase Beta-D-glucuronidase three Geranyltranstransferase Cytosine deaminase Diaminopimelate epimerase four Carbon Monoxide Dehydrogenase Prephenate dehydrogenase Beta-ketoacyl-acyl-carrier-protein synthase III 5 Prephenate dehydrogenase Cysteine synthase A Cysteine synthase A six Branched-chain-amino-acid transaminase Pyruvate-Formate Lyase Adenylosuccinate synthetase 7 Dihydrodipicolinate synthase Prephenate dehydrogenase Arginosuccinate synthase eight N-acetylmuramoyl-L-alanine amidase Quinolinate Synthase Cofactor Biosynthesis Amino acid synthesis Amino acid synthesis Respiration Glycan Biosynthesis and Metabolism Glycan structures – degradation;Exotic Metabolisms Isoprenoid biosynthesis Pyrimidine metabolism Amino acid synthesis Central Carbon Metabolism Pathways Amino acid synthesis Fatty Acid Biosynthesis Amino 16402044 acid synthesis Amino acid synthesis Amino acid synthesis Amino acid transport and metabolism Respiration Purine metabolism Amino acid synthesis Amino acid synthesis Amino acid synthesis Glycan Biosynthesis and Metabolism Cofactor Biosynthesis 241759137 fig_4440943.three.peg.33989 241760414 fig_4440944.three.peg.10065 218128624 218258198 237749332 229828779 fig_4440824.three.peg.204352 167748998 fig_4440943.three.peg.33989 227895174 fig_4440943.3.peg.33989 241760414 209907778 fig_4440610.3.peg.10420 fig_4440944.three.peg.10065 fig_4440949.3.peg.18491 229496628 fig_4440943.3.peg.33989 fig_4440939.3.peg.8046 218128624 227547856 9 Functional Gene Signature of Saliva Microbiota Gene name Pyruvate-Formate Lyase 9 Pyridoxal Kinase Serine hydroxymethyltransferase Prephenate dehydrogenase Each and every biomarker is often a triplet-feature set of microbial genes. doi:ten.1371/journal.pone.0076458.t002 Gene category Respiration.
